Strain Report - Rat Genome Database

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Strain: LA-cp/NJcr

Symbol: LA-cp/NJcr
Strain: LA-cp
Substrain: NJcr
RGD ID: 1642690
Citation ID: RRID:RGD_1642690
Ontology ID: RS:0001344
Also Known As: JCR:LA-cp;JCR:LA-corpulent rat; obese; LA/NJcr-cp; LA/NJcr-cp; LA-cp/NJcr
Type: congenic
Available Source: Not Available
Origination: Department of Surgery, University of Alberta, Edmonton, Canada
Description: Originated from a cross between ALB/N and a hooded stock of unknown origin; maintained at University of Alberta.
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats. Atkinson LL, etal., Diabetes. 2002 May;51(5):1548-55. doi: 10.2337/diabetes.51.5.1548.
2. MR molecular imaging of aortic angiogenesis. Cai K, etal., JACC Cardiovasc Imaging. 2010 Aug;3(8):824-32. doi: 10.1016/j.jcmg.2010.03.012.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Increased insulin sensitivity and reduced micro and macro vascular disease induced by 2-deoxy-D-glucose during metabolic syndrome in obese JCR: LA-cp rats. Russell JC and Proctor SD, Br J Pharmacol. 2007 May;151(2):216-25. Epub 2007 Mar 20.
5. Inhibition of atherosclerosis and myocardial lesions in the JCR:LA-cp rat by beta, beta'-tetramethylhexadecanedioic acid (MEDICA 16). Russell JC, etal., Arterioscler Thromb Vasc Biol. 1995 Jul;15(7):918-23.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics incorporates autosomal recessive corpulent gene; the extracellular domain of the ObR leptin receptor has a stop codon which is due to a mutation in the gene 1642391
strain_drgs_chems 14 days treatment with MEDICA 16 resulted in 80% decrease of plasma triglycerides and changed lipid metabolism 1642391

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-01-20 LA-cp/NJcr    LA/NJcr-cp  JCR:LA-corpulent rat  Symbol and/or name change 68913 APPROVED