Strain Report - Rat Genome Database

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Strain: MWF-Chr 6SHR/Rkb

Symbol: MWF-Chr 6SHR/Rkb
Strain: MWF-Chr 6SHR
Substrain: Rkb
RGD ID: 1641831
Citation ID: RRID:RGD_1641831
Ontology ID: RS:0001373
Previously known as: MWF-6SHR/Rkb; MWF-6SHR; MWF-6SHR; MWF-6SHR/Rkb;MWF-Chr 6SHR/Rkb; MWF-Chr 6SHR/Rkb
Type: consomic
Source: Department of Clinical Pharmacology and Toxicology, Charite-Universitatsmedizin Berlin, Berlin, Germany
Origin: MWF/FubRkb male was crossed with female SHR/FubRkb to get F1 animals which in turn were backcrossed with female MWF/FubRkb to preserve the Y chromosome, this was repeated for 7 generations, tested by sequential marker-assisted backcrossing
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. MWF rats with spontaneous albuminuria inherit a reduced efficiency of nephron induction during early nephrogenesis in comparison to SHR rats. Schulte L, etal., J Hypertens. 2012 Oct;30(10):2031-8. doi: 10.1097/HJH.0b013e328356a60a.
3. Protective effect of female gender on the development of albuminuria in a polygenetic rat model is further enhanced by replacement of a major autosomal QTL. Schulz A, etal., Clin Sci (Lond). 2007 Oct 22;.
4. Development of overt proteinuria in the Munich Wistar Fromter rat is suppressed by replacement of chromosome 6 in a consomic rat strain. Schulz A, etal., J Am Soc Nephrol. 2007 Jan;18(1):113-21. Epub 2006 Dec 13.


Strain QTL Data
Symbol Name Trait
Uae37 Urinary albumin excretion QTL 37 urine albumin amount   (VT:0002871)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Urinary albumin excretion in females was similar to female SHR/FubRkb rats. 1642911