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Strain Registration

Strain: SHRSP.WKY-(D1Wox29-D1Arb21)/Izm

Symbol: SHRSP.WKY-(D1Wox29-D1Arb21)/Izm
Strain: SHRSP.WKY-(D1Wox29-D1Arb21)
Substrain: Izm
RGD ID: 1600343
Citation ID: RRID:RGD_1600343
Ontology ID: RS:0001433
Also Known As: SHRSP.WKY-(D1Wox29-D1Arb21)/Izm; NBRP Rat No: 0221; SHRSPwch1.0; SPwch1.0
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This congenic strain contains an WKY/Izm chromsome 1 segment containing a blood pressure QTL transferred to a SHRSP/Izm background by using speed congenic strategy
Last Known Status: Cryopreserved Embryo
Research Usage Cardio Hypertension
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21123,350,408 - 182,418,476RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01130,779,148 - 199,254,774RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01131,822,204 - 206,277,202RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41124,614,679 - 187,092,492RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Relation of Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 to Hyperactivity of Rostralventrolateral Medulla. Iigaya K, etal., Hypertension. 2008 Dec 1.
2. Genetic effects of blood pressure quantitative trait Loci on hypertension-related organ damage: evaluation using multiple congenic strains. Ishikawa N, etal., Hypertens Res. 2008 Sep;31(9):1773-9.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. SYMPATHETIC REGULATION OF RENAL FUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS CONGENIC FOR CHROMOSOME 1 BLOOD PRESSURE QUANTITATIVE TRAIT LOCI. Wang T, etal., Clin Exp Pharmacol Physiol. 2008 Jun 18;.
5. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
6. A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. Xiao B, etal., J Hypertens. 2010 Nov 8.
7. Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Yao H, etal., Physiol Genomics. 2007 Feb 27;.

Region

Position Markers

Flank 1 / 1 (D1Wox29)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21123,350,408 - 123,350,581 (+)MAPPER
Rnor_6.01130,779,148 - 130,779,320NCBI
Rnor_5.01131,822,204 - 131,822,376UniSTS
RGSC_v3.41124,614,679 - 124,614,852RGD
RGSC_v3.41124,614,680 - 124,614,852UniSTS
RGSC_v3.11124,693,023 - 124,693,195RGD
Celera1115,524,239 - 115,524,411UniSTS
RH 3.4 Map11458.6RGD
RH 3.4 Map11458.6UniSTS

Flank 2 / 1 (D1Arb21)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21182,418,219 - 182,418,476 (+)MAPPER
Rnor_6.01199,254,518 - 199,254,774NCBI
Rnor_5.01206,276,946 - 206,277,202UniSTS
RGSC_v3.41187,092,235 - 187,092,492RGD
RGSC_v3.41187,092,236 - 187,092,492UniSTS
RGSC_v3.11187,242,116 - 187,242,373RGD
Celera1180,069,264 - 180,069,520UniSTS
FHH x ACI Map185.51UniSTS
FHH x ACI Map185.51RGD
Cytogenetic Map1q36UniSTS
Strain QTL Data
Symbol Name Trait
Bp298 Blood pressure QTL 298 arterial blood pressure trait   (VT:2000000)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Had higher stroke latency 2302104
strain_phys_biochem may have additional susceptibility genes for renal damage as had severe renal damage and median blood pressure 2302104
strain_phys_biochem Depolarization of RVLM neurons in response to angiotensin II was smaller than that of SHRSP/Izm 2302408

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-11 SHRSP.WKY-(D1Wox29-D1Arb21)/Izm    SHRSP.WKY-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED
2012-05-11 SHRSP.WKY-(D1Wox29-D1Arb21)/Izm    SHRSP.WKY-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED