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Strain: SHRSP/Bbb

Symbol: SHRSP/Bbb
Strain: SHRSP
Substrain: Bbb
RGD ID: 1581618
Citation ID: RRID:RGD_1581618
Ontology ID: RS:0001444
Previously known as: SHRSPHD
Type: inbred
Source: Max - Delbruck - Center for Molecular Medicine, Germany
Origin: This SHRSP colony as obtained from the original Japanese stock from Okamoto and Aoki in 1974 and is propagated by strict inbreeding. Now this colony is maintained at University of Heidelberg, Heidelburg, Germany.
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Mapping and confirmation of a major left ventricular mass QTL on rat chromosome 1 by contrasting SHRSP and F344 rats. Grabowski K, etal., Physiol Genomics. 2013 Sep 16;45(18):827-33. doi: 10.1152/physiolgenomics.00067.2013. Epub 2013 Jul 30.
2. Genome-wide searches for blood pressure quantitative trait loci in the stroke-prone spontaneously hypertensive rat of a Japanese colony. Kato N, etal., J Hypertens 2003 Feb;21(2):295-303.
3. Evidence for primary genetic determination of heart rate regulation: chromosomal mapping of a genetic locus in the rat. Kreutz R, etal., Circulation 1997 Aug 19;96(4):1078-81.
4. Dissection of a quantitative trait locus for genetic hypertension on rat chromosome 10. Kreutz R, etal., Proc Natl Acad Sci U S A 1995 Sep 12;92(19):8778-82.
5. Soluble epoxide hydrolase is a susceptibility factor for heart failure in a rat model of human disease. Monti J, etal., Nat Genet. 2008 May;40(5):529-37.
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. Ndufc2 Gene Inhibition Is Associated With Mitochondrial Dysfunction and Increased Stroke Susceptibility in an Animal Model of Complex Human Disease. Rubattu S, etal., J Am Heart Assoc. 2016 Feb 17;5(2). pii: e002701. doi: 10.1161/JAHA.115.002701.
8. Chromosomal mapping of quantitative trait loci contributing to stroke in a rat model of complex human disease Rubattu S, etal., Nat Genet 1996 Aug;13(4):429-34
9. Reciprocal congenic lines for a major stroke QTL on rat chromosome 1. Rubattu S, etal., Physiol Genomics. 2006 Oct 11;27(2):108-13. Epub 2006 Jul 11.
10. Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Sampson AK, etal., J Hypertens. 2014 Oct;32(10):2013-21; discussion 2021. doi: 10.1097/HJH.0000000000000300.


Strain QTL Data
Symbol Name Trait
Cm80 Cardiac mass QTL 80 heart left ventricle mass   (VT:0007031)    
Strs1 Sensitivity to stroke QTL 1 cerebrum integrity trait   (VT:0010549)    
Strs2 Sensitivity to stroke QTL 2 cerebrum integrity trait   (VT:0010549)    
Strs3 Sensitivity to stroke QTL 3 cerebrum integrity trait   (VT:0010549)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics stroke occurs by 6-7 weeks 2307158
strain_life_disease reduction in Ndufc2 expression leads to complex 1 dysfunction and contributes to stroke susceptibility 11040458