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Strain Registration

Strain: PCK-Pkhd1pck/CrljCrl

Symbol: PCK-Pkhd1pck/CrljCrl
Strain: PCK-Pkhd1pck
Substrain: CrljCrl
RGD ID: 1580542
Citation ID: RRID:RGD_1580542
Ontology ID: RS:0001381
Alleles: Pkhd1pck
Previously known as: PCK;PCK/CrljCrl-Pkhd1pck/Crl;PCK/CrljCrl-Pkhd1pck/Crl;PCK-Pkhd1pck/Crl; PCK/CrljCrl-Pkhd1pck/Crl
Type: coisogenic
Source: Charles River Laboratories
Origin: This model of polycystic kidney disease showing both kidney and liver involvement was identified in a colony of CD rats from the Charles River Japan production facility. The identification of the Pkhd1 gene mutation was reported by Harris and associates in 2002. This autosomal recessive Pkhd1 gene mutation is a model of human autosomal-recessive polycystic kidney disease (ARPKD).
Last Known Status: Unknown

Mutant Strains
PCK-P2rx7em8Mcwi




Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Characterization of a novel polycystic kidney rat model with accompanying polycystic liver. Katsuyama M, etal., Exp Anim. 2000 Jan;49(1):51-5.
2. The pck rat: a new model that resembles human autosomal dominant polycystic kidney and liver disease. Lager DJ, etal., Kidney Int 2001 Jan;59(1):126-36.
3. Role of genetic modifiers in an orthologous rat model of ARPKD. O'Meara CC, etal., Physiol Genomics. 2012 Aug 1;44(15):741-53. doi: 10.1152/physiolgenomics.00187.2011. Epub 2012 Jun 5.
4. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Polycystic kidney disease in Sprague-Dawley rats. Shoieb A and Shirai N, Exp Toxicol Pathol. 2015 May-Jun;67(5-6):361-4. doi: 10.1016/j.etp.2015.02.002. Epub 2015 Mar 6.
7. Effectiveness of vasopressin V2 receptor antagonists OPC-31260 and OPC-41061 on polycystic kidney disease development in the PCK rat. Wang X, etal., J Am Soc Nephrol. 2005 Apr;16(4):846-51. Epub 2005 Feb 23.
8. The gene mutated in autosomal recessive polycystic kidney disease encodes a large, receptor-like protein. Ward CJ, etal., Nat Genet 2002 Mar;30(3):259-69.
9. Genetic susceptibility and loss of Nr4a1 enhances macrophage-mediated renal injury in CKD. Westbrook L, etal., J Am Soc Nephrol. 2014 Nov;25(11):2499-510. doi: 10.1681/ASN.2013070786. Epub 2014 Apr 10.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Compared to CD®IGS, the body weight was identical for both males and females at 10 weeks but the increase was lower thereafter. 1580540
strain_characteristics Compared to CD¿IGS, the body weight was identical for both males and females at 10 weeks but the increase was lower thereafter. 1580540
strain_characteristics Compared to CDA?IGS, the body weight was identical for both males and females at 10 weeks but the increase was lower thereafter. 1580540
strain_drgs_chems Antagonist OPC-41061 and OPC-31260 inhibit Ras/mitogen-activated protein kianse signaling. 1580596
strain_life_disease Survival rate of males was 100% till 17 weeks and decreased gradually. Survival rate of females was 100% till 50 weeks and decreased gradually. 1580540
strain_life_disease Survival rate of males was 100% till 17 weeks and decreased gradually. Survival rate of females was 100% till 50 weeks and decreased gradually. 1580540
strain_phys_biochem The relative weight of both the kidneys and liver tends to increase with increasing age. 628435
strain_phys_biochem Cysts involve thickening of ascending loops of Henle, distal tubules, and cortical collecting ducts. 628435

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-04-23 PCK-Pkhd1pck/CrljCrl    PCK/CrljCrl-Pkhd1pck/Crl    Symbol updated 68687 APPROVED
2018-04-23 PCK-Pkhd1pck/CrljCrl    PCK/CrljCrl-Pkhd1pck/Crl    Symbol updated 68687 APPROVED