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Strain: FHH-Nr4a1m1Mcwi

Symbol: FHH-Nr4a1m1Mcwi
Strain: FHH-Nr4a1m1
Substrain: Mcwi
RGD ID: 1579706
RRID: RGD_1579706
Ontology ID: RS:0001132
Alleles: Nr4a1m1Mcwi
Also known as: FHH-Nr4a1m1Mcwi; Nr4a1-deficient rat; Nr4a1-/-
Type: mutant
Source: PhysGen
Origin: Male founders (FHH/EurMcwi) were injected with ENU (N-ethyl-N-nitrosourea) and harem bred to females. The pups were genetically screened using the TILLING assay (an enzyme-based heteroduplex cleavage assay) as well as nucleotide sequencing to identify and characterize target genes possessing ENU-induced mutations. Y130Stop mutation was generated from the codon change TAC/TAA.
Genetic Status: Homozygous
Last Known Status: Cryopreserved Sperm (as of 2017-01-26)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.27132,368,399 - 132,389,300RGD_MAPPER_PIPELINE
Rnor_6.07142,899,358 - 142,920,216RGD_MAPPER_PIPELINERnor6.0
Rnor_5.07140,700,242 - 140,721,073RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.47140,012,807 - 140,020,590RGD_MAPPER_PIPELINERGSC3.4





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Clinical Measurement
body weight
red blood cell count
blood hemoglobin level
blood neutrophil count
blood lymphocyte count
blood monocyte count
blood eosinophil count
hematocrit
mean corpuscular volume
blood urea nitrogen level
plasma anion gap
heart wet weight
heart left ventricle wet weight
heart right ventricle wet weight
heart weight to body weight ratio
body length, nose to tail
body length, nose to rump
left kidney wet weight
timed urine volume
mean corpuscular hemoglobin level
mean corpuscular hemoglobin concentration
both kidneys wet weight to body weight ratio
serum triglyceride level
serum total cholesterol level
total white blood cell count
total serum bilirubin level
serum bicarbonate level
serum chloride level
serum potassium level
serum sodium level
serum calcium level
plasma creatinine level
serum phosphate level
serum glucose level
serum albumin level
serum alanine aminotransferase activity level
serum alkaline phosphatase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
liver weight to body weight ratio
serum total protein level
concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)
logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)
concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
maximum contractile force per wet weight of aorta
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
water drink intake rate
urine albumin excretion rate to body weight ratio
creatinine clearance to total kidney weight ratio
serum globulin level

References


Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-03-21 FHH-Nr4a1m1Mcwi    FHH-Nr4a1m1Mcwi    Symbol updated 68687 APPROVED
2014-03-21 FHH-Nr4a1m1Mcwi    FHH-Nr4a1m1Mcwi    Symbol updated 68687 APPROVED
2014-03-21 FHH-Nr4a1m1Mcwi    FHH-Nr4a1m1Mcwi    Name updated 68913 APPROVED
2014-03-21 FHH-Nr4a1m1Mcwi    FHH-Nr4a1m1Mcwi    Name updated 68913 APPROVED
2013-08-12 FHH-Nr4a1m1Mcwi    FHH-Nr4a1m1Mcwi    Name updated 68913 APPROVED
2013-08-12 FHH-Nr4a1m1Mcwi    FHH-Nr4a1m1Mcwi    Name updated 68913 APPROVED