Strain Report - Rat Genome Database

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Strain: LEW.1AR1-iddm/Ztm

Symbol: LEW.1AR1-iddm/Ztm
Strain: LEW.1AR1-iddm
Substrain: Ztm
RGD ID: 1578710
Citation ID: RRID:RGD_1578710
Ontology ID: RS:0001353
Alleles: Dock8m1Ztm
Also Known As: LEW.1AR1-iddm/Ztm
Type: coisogenic
Available Source: Not Available
Origination: Institute for Laboratory Animal Science, Hannover Medical School, Hanover, Germany
Description: arose through a spontaneous mutation in a congenic Lewis strain with a defined MHC haplotype (RT1.AaB/DuCu) in the intra-MHC recombinant inbred strain LEW.1AR1; mutation was discovered in Fx + 13 of the LEW.1AR1 and has been maintained as a separate strain since
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human type 1 diabetes. Arndt T, etal., Diabetologia. 2015 Dec;58(12):2800-9. doi: 10.1007/s00125-015-3757-7. Epub 2015 Sep 12.
2. The LEW.1AR1/Ztm-iddm rat: a new model of spontaneous insulin-dependent diabetes mellitus. Lenzen S, etal., Diabetologia. 2001 Sep;44(9):1189-96. doi: 10.1007/s001250100625.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Genetic analysis of the LEW.1AR1-iddm rat: an animal model for spontaneous diabetes mellitus. Weiss H, etal., Mamm Genome 2005 Jun;16(6):432-41.


Strain QTL Data
Symbol Name Trait
Iddm21 Insulin dependent diabetes mellitus QTL 21 blood glucose amount   (VT:0000188)    
Iddm22 Insulin dependent diabetes mellitus QTL 22 blood glucose amount   (VT:0000188)    
Iddm23 Insulin dependent diabetes mellitus QTL 23 blood glucose amount   (VT:0000188)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_immunology animals exhibit autoimmune destruction of pancreatic beta cells causing type 1 diabetes 1547853
strain_life_disease animals develop a type 1 diabetes syndrome around day 60 after birth as a result of a rapid autoimmune destruction of pancreatic beta cells. The diabetic syndrome in the backcross population is characterized by hyperglycemia (> 10 mmol/L), weight loss, polydypsia, polyuria, glucosuria,and ketonuria 1547853
strain_other autosomal recessive model of inheritance for diabetes susceptibility/diabetes inducing gene, hypothesized to have several diabetes susceptibility loci 1547853