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Strain: SHR.ODS-Gulood/Shi

Symbol: SHR.ODS-Gulood/Shi
Strain: SHR.ODS-Gulood
Substrain: Shi
RGD ID: 1559048
Citation ID: RRID:RGD_1559048
Ontology ID: RS:0001420
Alleles: Gulo
Also Known As: SHR-od; NBRP Rat No: 0081; SHR.ODS-Gulood/Shi; SHR.ODS-Gulo^[od]/Shi
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: A congenic strain developed from a recipient, SHR and a donor, ODS. The first generation was backcrossed to SHR and these rats were genotyped and the heterozygous rats were backcrossed to SHR to generate the congenics. Introduced to Nagoya University in 1995.
Coat Color: Albino
Inbred Generations: F18
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Cardio Hypertension; Osteosis





Disease Annotations     Click to see Annotation Detail View
hypertension  (IAGP)
scurvy  (IAGP)


Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
urine sodium excretion rate to body weight ratio
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis. Horio F, etal., Life Sci 2001 Sep 7;69(16):1879-90.
2. Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid. Kawai K, etal., Life Sci 2003 Feb 28;72(15):1717-32.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease In males, systolic blood pressure increases at 8 weeks of age and reaches a plateau at 18-20 weeks of age which is maintained till 42 weeks of age. Females too have age dependent blood pressure. 1556471
strain_phys_biochem These rats are unable to synthesize ascorbic acid. 1556471

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-25 SHR.ODS-Gulood/Shi    SHR.ODS-Gulood/Shi    Name updated 68913 APPROVED
2016-08-25 SHR.ODS-Gulood/Shi    SHR.ODS-Gulood/Shi    Name updated 68913 APPROVED
2012-05-09 SHR.ODS-Gulood/Shi    SHR.ODS-Gulood/Shi    Name updated 68913 APPROVED
2012-05-09 SHR.ODS-Gulood/Shi    SHR.ODS-Gulood/Shi    Name updated 68913 APPROVED
2012-05-09 SHR.ODS-Gulood/Shi    SHR.ODS-Gulood/Shi    Name updated 68913 APPROVED
2012-05-09 SHR.ODS-Gulood/Shi    SHR.ODS-Gulood/Shi    Name updated 68913 APPROVED