Strain Report - Rat Genome Database

Name: SHR.ODS- Gulo od /Shi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SHR.ODS-Gulo^od/Shi
Symbol:	SHR.ODS-Gulo^od/Shi
Strain:	SHR.ODS-Gulo^od
Substrain:	Shi
RGD ID:	1559048
Citation ID:	RRID:RGD_1559048
Ontology ID:	RS:0001420
Alleles:	Gulo
Previously known as:	SHR-od; NBRP Rat No: 0081; SHR.ODS-Gulood/Shi
Type:	congenic
Source:	National BioResource Project for the Rat in Japan
Origin:	A congenic strain developed from a recipient, SHR and a donor, ODS. The first generation was backcrossed to SHR and these rats were genotyped and the heterozygous rats were backcrossed to SHR to generate the congenics. Introduced to Nagoya University in 1995.
Coat Color:	Albino
Inbred Generations:	F18
Last Known Status:	Cryopreserved Embryo; Cryopreserved Sperm
Research Usage	Cardio Hypertension; Osteosis

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypertension (IAGP)

scurvy (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased alkaline phosphatase activity (IDA)

decreased body weight (IAGP)

decreased circulating vitamin C level (IAGP)

decreased liver vitamin C level (IDA)

decreased systemic arterial systolic blood pressure (IDA)

decreased testicular artery wall-to-lumen ratio (IDA)

increased heart weight (IAGP,IDA)

increased liver weight (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

systolic blood pressure

body weight

body temperature

red blood cell count

blood hemoglobin level

white blood cell count

platelet count

hematocrit

mean corpuscular volume

plasma glucose level

plasma aspartate aminotransferase activity level

plasma alanine aminotransferase activity level

plasma alkaline phosphatase activity level

plasma total protein level

plasma albumin level

plasma phosphate level

plasma chloride level

plasma sodium level

plasma potassium level

heart wet weight

heart weight to body weight ratio

both kidneys wet weight

lung wet weight

urine potassium level

urine sodium level

brain weight to body weight ratio

both kidneys wet weight as percentage of body weight

liver weight as percentage of body weight

spleen weight to body weight ratio

brain wet weight

lung weight to body weight ratio

liver wet weight

both adrenal glands wet weight

spleen wet weight

both testes wet weight

activated partial thromboplastin time

prothrombin time

timed urine volume

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

blood basophil count to total leukocyte count ratio

blood eosinophil count to total leukocyte count ratio

blood lymphocyte count to total leukocyte count ratio

blood monocyte count to total leukocyte count ratio

total plasma calcium level

urine chloride level

plasma creatinine level

plasma triglyceride level

plasma total cholesterol level

plasma urea nitrogen level

both adrenal glands weight to body weight ratio

plasma high density lipoprotein cholesterol level

plasma low density lipoprotein cholesterol level

both testes wet weight to body weight ratio

urine sodium excretion rate to body weight ratio

timed urine volume to body weight ratio

urine chloride excretion rate to body weight ratio

urine potassium excretion rate to body weight ratio

plasma total bilirubin level

blood segmented neutrophil count to total leukocyte count ratio

blood band neutrophil count to total leukocyte count ratio

non-specified leukocyte count to total leukocyte count ratio

plasma albumin to plasma total protein ratio

References

References - curated

#	Reference Title	Reference Citation
1.	A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis.	Horio F, etal., Life Sci 2001 Sep 7;69(16):1879-90.
2.	Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid.	Kawai K, etal., Life Sci 2003 Feb 28;72(15):1717-32.
3.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_life_disease	In males, systolic blood pressure increases at 8 weeks of age and reaches a plateau at 18-20 weeks of age which is maintained till 42 weeks of age. Females too have age dependent blood pressure.	1556471
strain_phys_biochem	These rats are unable to synthesize ascorbic acid.	1556471

Nomenclature History

Date	Current Symbol	Previous Symbol	Description	Reference	Status
2016-08-25	SHR.ODS-Gulo^od/Shi	SHR.ODS-Gulo^od/Shi	Name updated	68913	APPROVED
2016-08-25	SHR.ODS-Gulo^od/Shi	SHR.ODS-Gulo^od/Shi	Name updated	68913	APPROVED
2012-05-09	SHR.ODS-Gulo^od/Shi	SHR.ODS-Gulo^od/Shi	Name updated	68913	APPROVED
2012-05-09	SHR.ODS-Gulo^od/Shi	SHR.ODS-Gulo^od/Shi	Name updated	68913	APPROVED
2012-05-09	SHR.ODS-Gulo^od/Shi	SHR.ODS-Gulo^od/Shi	Name updated	68913	APPROVED
2012-05-09	SHR.ODS-Gulo^od/Shi	SHR.ODS-Gulo^od/Shi	Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Strain: SHR.ODS-Gulo^od/Shi

Mammalian Phenotype

Related Phenotype Data for Term "SHR.ODS-Gulood/Shi" (RS:0001420)

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Strain: SHR.ODS-Gulood/Shi

Mammalian Phenotype

Related Phenotype Data for Term "SHR.ODS-Gulood/Shi" (RS:0001420)

Strain: SHR.ODS-Gulo^od/Shi