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Strain Registration

Strain: ODS/Shi

Symbol: ODS/Shi
Strain: ODS
Substrain: Shi
Full Name: Osteogenic disorder Shionogi
RGD ID: 1559039
Citation ID: RRID:RGD_1559039
Ontology ID: RS:0001378
Previously known as: ODS; ODS/Shi (od/od)
Type: mutant
Source: Shionogi & Co., Ltd. Japan
Origin: Dr. Susumu Makino and his colleagues found several animals that had gait abnormalities among Wistar rats maintained at Shionogi Co. They named these animals osteogenic disorder (OD) rats because they exhibited prominent bone and joint abnormalities and systemic bleeding. Subsequent studies revealed that these symptoms were derived from an ascorbic acid (vitamin C) deficiency arising from defective gulonolactone oxidase (GLO) activity. This characteristic was confirmed to be the result of a mutation involving the autosomal single recessive gene od. Scurvy due to L-gulonolactone oxidase deficincy; phenotype normalizes if supplied with ascorbic acid 300mg/kg/d. od/od rats are more susceptible to dental caries as compared with +/+ rats, in only amoun parous females.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View
scurvy  (IAGP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. A newly established strain of spontaneously hypertensive rat with a defect of ascorbic acid biosynthesis. Horio F, etal., Life Sci 2001 Sep 7;69(16):1879-90.
2. Changes in catecholamine metabolism by ascorbic acid deficiency in spontaneously hypertensive rats unable to synthesize ascorbic acid. Kawai K, etal., Life Sci 2003 Feb 28;72(15):1717-32.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem These rats have mutated Gulo gene, this enzyme catalyzes the last step of ascorbic acid biosynthesis. 1556471

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-04-30 ODS/Shi  Osteogenic disorder Shionogi  ODS/Jcl  Osteogenic disorder Shionogi  Symbol and/or name change 68913 APPROVED
2010-08-25 ODS/Jcl  Osteogenic disorder Shionogi  ODS/ShiJcl  Osteogenic disorder Shionogi  Name/symbol updated 68913 APPROVED