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Strain: SD-Pde3aem3Bdr

Symbol: SD-Pde3aem3Bdr
Strain: SD-Pde3aem3
Substrain: Bdr
RGD ID: 155631298
Citation ID: RRID:RGD_155631298
Ontology ID: RS:0005180
Alleles: Pde3aem3Bdr
Also Known As: SD-Pde3a^[em3Bdr]
Type: mutant
Available Source: Not Available
Origination: Max-Delbr'ck-Center for Molecular Medicine (MDC) in the Helmholtz Association, Berlin, Germany
Description: The rat mutant was generated by pronuclear microinjection of Sprague-Dawley rat zygotes with a mixture of Cas9/Cas9 system to target the catalytic domain in the rat Pde3a gene. The model has a carriesa CGT to TGD missense mutation and results in R862C substitutions in the protein
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.24174,172,804 - 174,443,944RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.04175,431,904 - 175,703,844RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04239,659,270 - 239,921,900RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.44178,658,896 - 178,930,417RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Mutant Phosphodiesterase 3A Protects From Hypertension-Induced Cardiac Damage. Ercu M, etal., Circulation. 2022 Oct 19:101161CIRCULATIONAHA122060210. doi: 10.1161/CIRCULATIONAHA.122.060210.

Region


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