Strain Report - Rat Genome Database

Name: SD- Bmal1 em1Mcwi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Bmal1^em1Mcwi

Symbol:

SD-Bmal1^em1Mcwi

Strain:

SD-Bmal1^em1

Substrain:

Mcwi

RGD ID:

155598601

Citation ID:

RRID:RGD_155598601

Ontology ID:

RS:0005170

Alleles:

Bmal1^em1Mcwi

Type:

mutant

Source:

MCW Gene Editing Rat Resource Center; Contact MCW rat distribution at mcwcustomrats@mcw.edu

Origin:

CRISPR/Cas9 system was used to introduce a 58-base pair deletion in exon 6 in the rat Bmal1 gene of Crl:SD embryos. The deletion caused a premature stop codon in exon 6 resulting in a severe truncation of the Bmal1 protein.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	167,331,756 - 167,430,235	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	178,039,002 - 178,137,469	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	185,007,527 - 185,105,413	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	171,062,181 - 171,162,426	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal urine sodium level (IMP)

decreased body weight (IMP)

decreased food intake (IMP)

decreased mean systemic arterial blood pressure (IMP)

decreased systemic arterial diastolic blood pressure (IMP)

decreased systemic arterial systolic blood pressure (IMP)

increased heart rate (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Diurnal Control of Blood Pressure Is Uncoupled From Sodium Excretion.	Johnston JG, etal., Hypertension. 2020 Jun;75(6):1624-1634. doi: 10.1161/HYPERTENSIONAHA.119.13908. Epub 2020 Apr 20.

Region

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Bmal1em1Mcwi

Mammalian Phenotype

Strain: SD-Bmal1^em1Mcwi