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Strain Registration

Strain: CVD/Opu

Symbol: CVD/Opu
Strain: CVD
Substrain: Opu
Full Name: Cerebellar vermis defect rat
RGD ID: 1554303
Citation ID: RRID:RGD_1554303
Ontology ID: RS:0000469
Alleles: Unc5c
Type: inbred
Available Source: Not Available
Origination: Department of Veterinary Pathology, Osaka Prefecture University, Sakai, Osaka, Japan
Description: Originated from a colony of Lewis rats that were spontaneously ataxic. Maintained by brother-sister mating with phenotypically normal littermates.
Last Known Status: Unknown






References

References - curated
# Reference Title Reference Citation
1. Glial pathology in development of cerebellar dysplasia in the hereditary cerebellar vermis defect (CVD) rat. Kuwamura M, etal., Acta Neuropathol (Berl) 2000 Mar;99(3):305-9.
2. Hereditary cerebellar vermis defect in the Lewis rat. Kuwamura M, etal., Brain Res Dev Brain Res 1994 Dec 16;83(2):294-8.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy Perivascular aggregation of external granule cells (EGCs) is observed during postnatal cerebellar development. 1302460
strain_characteristics They have fused cerebellar hemisphere which leads to cerebellar vermis defects and dysplasia in the cerebellum. 1302460
strain_life_disease From 14 days of age they develop hind-leg paralysis leading to heriditary cerebellar vermis defect. 1553899
strain_life_disease Predicted to have truncated Unc5c protein that is expressed in the brain. 1302733
strain_other These are neurological mutant rats that are used as a model for the pathogenesis of cerebellar vermis defect (CVD) due to genetic insults. 1302460