Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: SD-Tg(Cyp2e1-CYP2E1*-Cas9)SynblRrrc

Symbol: SD-Tg(Cyp2e1-CYP2E1*-Cas9)SynblRrrc
Strain: SD-Tg(Cyp2e1-CYP2E1*-Cas9)
Substrain: SynblRrrc
RGD ID: 155260363
Citation ID: RRID:RGD_155260363
Ontology ID: RS:0005163
Also Known As: SD-Tg(Cyp2e1-CYP2E1*-Cas9) Rrrc; SD-Tg(Cyp2e1-CYP2E1*-Cas9)Rrrc
Type: transgenic
Available Source: RRRC
Description: rat strain in which the rat Cyp2e1 gene is humanized by insertion of a human CYP2E1 minigene (CYP2E1*) insert at the native start codon. The insert also included a CRISPR/Cas9 gene drive element to enable super-Mendelian inheritance of the modified allele when crossed to a rat expressing Cas9 in the germline. ROBUST AND EFFICIENT ACTIVE GENETICS GENE CONVERSION IN THE RAT AND MOUSE Chenyen Lai, Oscar Alvarez, Kristen Read, Don van Fossan,Christopher M Conner, Shannon Xaing-Ru Xu, Dale O. Cowley, Valentino Gantz, David R. Webb, Kurt Jarnagin URL: Doi:10.1101/2022.08.30.505951 URL: Doi:10.1101/2022.08.30.505951 URL: URL: Doi:10.1101/2022.08.30.505951
Genetic Status: Heterozygous
Last Known Status: Cryopreserved Sperm (as of 2022-10-06)
Research Usage Genetics, Reproductive Biology, Gene Conversion, Active Genetics, Drug Metabolism, Cyp450






References

References - curated
# Reference Title Reference Citation
1. Strains registration through online submission tool Strains registered through the Online Strain Submission Tool

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-06 SD-Tg(Cyp2e1-CYP2E1*-Cas9)SynblRrrc    SD-Tg(Cyp2e1-CYP2E1*-Cas9)Rrrc    Symbol and/or name change 68913 APPROVED
2022-10-06 SD-Tg(Cyp2e1-CYP2E1*-Cas9)Rrrc    SD-Tg(Cyp2e1-CYP2E1*-Cas9) Rrrc    Symbol and/or name change 68913 APPROVED