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Strain Registration

Strain: SD-Slc9a6 em1Moro

Symbol: SD-Slc9a6 em1Moro
Strain: SD-Slc9a6 em1
Substrain: Moro
RGD ID: 151664748
Citation ID: RRID:RGD_151664748
Ontology ID: RS:0005139
Alleles: Slc9a6 em1Moro
Also Known As: NHE6-null rat; SD-Slc9a6 ^[em1Moro]
Type: mutant
Available Source: Not Available
Origination: Organization: Dr. Eric Morrow at Brown University 70 Ship Street, Box G-E4 Providence RI 02912 USA
Description: CRISPR/Cas9 system was used to generate this mutant. Guide RNA sequence is the following: 5'-CGGCTGTGTAACCCTGATGA-3'. Cas9-mediated cleavage at exon 7 in the Slc9a6 locus resulted in the insertion of 2 bp (TT) generating frameshift and a premature stop codon.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2X134,443,830 - 134,443,831RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0X158,979,081 - 159,045,019RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0X153,620,082 - 153,675,717RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4X141,146,237 - 141,201,234RGD_MAPPER_PIPELINERGSC3.4

Mutant Strains
SD-Slc9a6 em1Moro/Rrrc




References

References - curated
# Reference Title Reference Citation
1. Early lysosome defects precede neurodegeneration with amyloid-β and tau aggregation in NHE6-null rat brain. Lee Y, etal., Brain. 2021 Dec 20. pii: 6470622. doi: 10.1093/brain/awab467.

Region


Additional Information