Strain Report - Rat Genome Database

Name: SD- Tbc1d1 Tn(sb)1Fkh
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) (beta) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer) Overgo Probe Designer Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Strain Registration

General

Strain: SD-Tbc1d1^Tn(sb)1Fkh

Symbol:

SD-Tbc1d1^Tn(sb)1Fkh

Strain:

SD-Tbc1d1^Tn(sb)1

Substrain:

Fkh

RGD ID:

150521708

Citation ID:

RRID:RGD_150521708

Ontology ID:

RS:0005114

Alleles:

Tbc1d1^Tn(sb)1Fkh

Previously known as:

TBC1D1 KO rat; SD-Tbc1d1^Tn(sb)Fkh

Type:

mutant

Source:

University of Texas Southwestern Medical Center, Dallas TX

Origin:

The Sleeping Beauty transposon-mediated mutagenesis was used to knock out the rat Tbc1d1 gene in in rat spermatogonial stem cells from Sprague Dawley.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	14	43,936,820 - 44,135,133	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	14	45,598,753 - 45,797,650	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	14	45,404,208 - 45,603,325	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	14	46,594,874 - 46,781,813	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal carbohydrate metabolism (IMP)

abnormal endocrine pancreas physiology (IMP)

abnormal respiratory function (IMP)

decreased circulating insulin level (IMP)

decreased fasting circulating glucose level (IMP)

decreased insulin secretion (IMP)

decreased muscle cell glucose uptake (IMP)

decreased pancreatic beta cell mass (IMP)

increased apoptosis (IMP)

increased circulating glucose level (IMP)

increased creatine level (IMP)

increased fasting circulating glucose level (IMP)

increased fatty acid oxidation (IMP)

increased muscle fatigability (IMP)

increased oxygen consumption (IMP)

increased skeletal muscle glycogen level (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	The Rab-GTPase activating protein, TBC1D1, is critical for maintaining normal glucose homeostasis and β-cell mass.	Paglialunga S, etal., Appl Physiol Nutr Metab. 2017 Jun;42(6):647-655. doi: 10.1139/apnm-2016-0585. Epub 2017 Jan 31.
2.	Strains registration through online submission tool	Strains registered through the Online Strain Submission Tool
3.	Ablating the protein TBC1D1 impairs contraction-induced sarcolemmal glucose transporter 4 redistribution but not insulin-mediated responses in rats.	Whitfield J, etal., J Biol Chem. 2017 Oct 6;292(40):16653-16664. doi: 10.1074/jbc.M117.806786. Epub 2017 Aug 14.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-11-16	SD-Tbc1d1^Tn(sb)1Fkh		SD-Tbc1d1^Tn(sb)Fkh		Symbol and/or name change	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Create Name:

Description:

Send us a Message

Strain: SD-Tbc1d1Tn(sb)1Fkh

Mammalian Phenotype

Strain: SD-Tbc1d1^Tn(sb)1Fkh