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Strain Registration

Strain: SD-Gfapem2Mes /Rrrc

Symbol: SD-Gfapem2Mes /Rrrc
Strain: SD-Gfapem2Mes
Substrain: Rrrc
RGD ID: 150519896
Citation ID: RRID:RRRC_00931
Ontology ID: RS:0005073
Alleles: Gfapem2Mes
Also Known As: Gfap-null; SD-Gfap^[em2Mes] /Rrrc
Type: mutant
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: CRISPR/Cas9 mediated single nucleotide deletion resulting in a frameshift that creates a premature stop and generates a null allele. This strain serves as a model for Alexander disease - nulls are of interest for traumatic brain injury and many other studies of CNS disease and astrocyte response.
Genetic Status: Heterozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21087,852,891 - 87,861,631RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01090,990,762 - 90,999,435RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01090,763,150 - 90,771,823RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41092,059,881 - 92,068,555RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Antisense therapy in a new rat model of Alexander disease reverses GFAP pathology, white matter deficits, and motor impairment. Preprint bioRxiv. Tracy L. Hagemann, Berit Powers, Ni-Hsuan Lin, Ahmed F. Mohamed, Katerina L. Dague, Seth C. Hannah, Curt Mazur, Frank Rigo, Mel B. Feany, Ming-Der Perng, Robert F. Berman, Albee Messing

Region


Additional Information

Database Acc Id Source(s)
RRRC RRRC:00931 RGD