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Strain: SD-Gnalem1Hpng-/-

Symbol: SD-Gnalem1Hpng-/-
Strain: SD-Gnalem1-/-
Substrain: Hpng
RGD ID: 150429817
Citation ID: RRID:RGD_150429817
Ontology ID: RS:0005059
Alleles: Gnalem1Hpng
Also Known As: SD-Gnal^[em1Hpng-/-]
Type: mutant
Available Source: Not Available
Origination: Core Facility Transgenic Animals, University Clinics Tuebingen, Tuebingen, Germany
Description: Thehomozygous Gnal mutant rats were created by CRISPR/Cas9. Guide RNA sequences targeting the first exon of the rat Gnal gene isoform 2 were designed. The mutated allele contained a 13- bp deletion in exon1 that corresponded to position 34 to 46 downstream of the translation start point ATG of the Gnal splicing variant 2 was detected resulting in an early stop at position 150 and producing a truncated protein with 50 amino acids. Only 5% of homozygous Gnal knockout mice could survive till maturity
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21860,622,311 - 60,762,599RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01862,805,406 - 62,946,133RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01861,991,738 - 62,131,420RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41863,595,606 - 63,735,803RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View
dystonia  (IMP)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype


References - curated
# Reference Title Reference Citation
1. Impaired dopamine- and adenosine-mediated signaling and plasticity in a novel rodent model for DYT25 dystonia. Yu-Taeger L, etal., Neurobiol Dis. 2020 Feb;134:104634. doi: 10.1016/j.nbd.2019.104634. Epub 2019 Oct 31.


Additional Information