Strain Report - Rat Genome Database

Name: SHRSP.SHR-( rs197197017 -rs198445122 )/Utx
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SHRSP.SHR-(rs197197017 -rs198445122)/Utx

Symbol:

SHRSP.SHR-(rs197197017 -rs198445122)/Utx

Strain:

SHRSP.SHR-(rs197197017 -rs198445122)

Substrain:

Utx

RGD ID:

150340617

Citation ID:

RRID:RGD_150340617

Ontology ID:

RS:0005009

Previously known as:

SHR-A3(Stim1-B2); SHRSP.SHR-(rs106374972-rs106170276)/Utx

Type:

congenic

Source:

University of Texas, Houston, TX

Origin:

A congenic strain made by introducing B2 fragment (a segment of chromosome 1, 154.7 Mb - 203 Mb) from SHR/Utx into SHRSP/BbbUtx.The B2 fragment contains wild-type Stim1 as confirmed by sequencing.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
Rnor_6.0	1	156,969,388 - 198,720,287	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	163,213,339 - 205,713,847	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	148,969,064 - 186,536,846	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal calcium level (IAGP)

albuminuria (IAGP)

decreased IgG level (IAGP)

decreased interleukin-2 secretion (IAGP)

increased B cell number (IAGP)

increased CD4-positive, alpha-beta T cell number (IAGP)

increased CD8-positive, alpha-beta T cell number (IAGP)

increased IgM level (IAGP)

increased T cell apoptosis (IAGP)

increased T cell number (IAGP)

increased urine HAVCR1 level (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Natural genetic variation in Stim1 creates stroke in the spontaneously hypertensive rat.	Dhande IS, etal., Genes Immun. 2020 May;21(3):182-192. doi: 10.1038/s41435-020-0097-5. Epub 2020 Apr 17.
2.	Stim1 Polymorphism Disrupts Immune Signaling and Creates Renal Injury in Hypertension.	Dhande IS, etal., J Am Heart Assoc. 2020 Mar 3;9(5):e014142. doi: 10.1161/JAHA.119.014142. Epub 2020 Feb 20.

Region

Position Markers

Flank 1 / 1 (rs197197017)

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	156,969,388 - 156,969,388	RGD
Rnor_5.0	1	163,213,339 - 163,213,339	RGD
RGSC_v3.4	1	148,969,064 - 148,969,064	RGD

Flank 2 / 1 (rs198445122)

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	198,720,287 - 198,720,287	RGD
Rnor_5.0	1	205,713,847 - 205,713,847	RGD
RGSC_v3.4	1	186,536,846 - 186,536,846	RGD

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2021-10-04	SHRSP.SHR-(rs197197017 -rs198445122)/Utx		SHRSP.SHR-(rs106374972-rs106170276)/Utx		Symbol and/or name change	68913	APPROVED
2021-09-10	SHRSP.SHR-(rs106374972-rs106170276)/Utx		SHRSP.SHR-(rs149735373-rs106170276)/Utx		Symbol and/or name change	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SHRSP.SHR-(rs197197017 -rs198445122)/Utx

Mammalian Phenotype