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Strain Registration

Strain: SD-Wfs1em3Ptsn

Symbol: SD-Wfs1em3Ptsn
Strain: SD-Wfs1em3
Substrain: Ptsn
RGD ID: 149735338
Citation ID: RRID:RGD_149735338
Ontology ID: RS:0004970
Alleles: Wfs1em3Ptsn
Previously known as: Wfs1-ex5-INS244; SD-Wfs1em3
Type: mutant
Source: Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu,
Origin: Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em3 rats carry a substitution in exon 5 of the Wfs1 gene, which is predicted to result in a substitution of LQK (aa 224-226) into YCMNTI in the WFS1 protein.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21473,810,478 - 73,834,993RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01478,640,707 - 78,665,224RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01478,606,172 - 78,630,689RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41479,379,680 - 79,404,003RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-23 SD-Wfs1em3Ptsn    SD-Wfs1em3    Symbol and/or name change 68913 APPROVED