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Strain: SD-Wfs1em1Ptsn

Symbol: SD-Wfs1em1Ptsn
Strain: SD-Wfs1em1
Substrain: Ptsn
RGD ID: 149735334
Citation ID: RRID:RGD_149735334
Ontology ID: RS:0004968
Alleles: Wfs1em1Ptsn
Also Known As: SD-Wfs1em1; Wfs1-ex5-KO232; SD-Wfs1^[em1Ptsn]
Type: mutant
Available Source: Not Available
Origination: Institute of Biomedicine and Translational Medicine, Department of Physiology, University of Tartu,
Description: Rat Wfs1 exon 5-specific zinc-finger nucleases (ZNFs) and microinjection-ready mRNA were injected to embryos harvested from female Sprague-Dawley rats (Crl: CD(SD) )rats. Thereafter, microinjected egg cells were transferred to the oviduct of pseudopregnant Sprague-Dawley recipients.Three different Wfs1 mutant rat lines were created: Wfs1em1 ( Wfs1-ex5-KO232), Wfs1em2 (Wfs1-ex5-KO266) and Wfs1em3 (Wfs1-ex5-INS244). Wfs1em1 rats carry a 184 bp deletion, resulting 27 amino acids deletion in exon 5 (aa212-238) and a new GCC codon(alanine).
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21473,810,478 - 73,834,993RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01478,640,707 - 78,665,224RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01478,606,172 - 78,630,689RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41479,379,680 - 79,404,003RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Wfs1- deficient rats develop primary symptoms of Wolfram syndrome: insulin-dependent diabetes, optic nerve atrophy and medullary degeneration. Plaas M, etal., Sci Rep. 2017 Aug 31;7(1):10220. doi: 10.1038/s41598-017-09392-x.
2. Preventive treatment with liraglutide protects against development of glucose intolerance in a rat model of Wolfram syndrome. Toots M, etal., Sci Rep. 2018 Jul 5;8(1):10183. doi: 10.1038/s41598-018-28314-z.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-07-23 SD-Wfs1em1Ptsn    SD-Wfs1em1    Symbol and/or name change 68913 APPROVED
2021-07-15 SD-Wfs1em1    SD-Wfs1em1Ptsn    Symbol and/or name change 68913 APPROVED