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Strain: LE-Chrna5em20(D398N)Pas

Symbol: LE-Chrna5em20(D398N)Pas
Strain: LE-Chrna5em20(D398N)
Substrain: Pas
RGD ID: 14402421
Citation ID: RRID:RGD_14402421
Ontology ID: RS:0004713
Alleles: Chrna5em20(D398N)Pas
Also Known As: alph 5SNP rat; LE-Chrna5^[em20(D398N)Pas]
Type: mutant
Available Source: Not Available
Origination: Strains were produced at Institut Pasteur (France), Departement de Neuroscience, Benoit Forget. The lines will be maintained at Charles River Laboratory France (CRLF).
Description: The Zinc Finger Nuclease system was used to knock-in SNP rs16969968 in exon 5 (D398N) thus created a missense mutation. The embryos were from breeding of Long Evans from Janvier Labs (RjOrl:LE) and reimplanted to foster mother Dark Agouti (Janvier). Heterozygous rats are currently bred to generate heterozygous and homozygous.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2855,369,794 - 55,398,526RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0859,561,817 - 59,590,172RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0858,143,974 - 58,172,330RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4858,538,002 - 58,566,388RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Profound alteration in reward processing due to a human polymorphism in CHRNA5: a role in alcohol dependence and feeding behavior. Besson M, etal., Neuropsychopharmacology. 2019 Oct;44(11):1906-1916. doi: 10.1038/s41386-019-0462-0. Epub 2019 Jul 9.
2. A Human Polymorphism in CHRNA5 Is Linked to Relapse to Nicotine Seeking in Transgenic Rats. Forget B, etal., Curr Biol. 2018 Oct 22;28(20):3244-3253.e7. doi: 10.1016/j.cub.2018.08.044. Epub 2018 Oct 4.
3. Alterations in nicotinic receptor alpha5 subunit gene differentially impact early and later stages of cocaine addiction: a translational study in transgenic rats and patients. Forget B, etal., Prog Neurobiol. 2021 Feb;197:101898. doi: 10.1016/j.pneurobio.2020.101898. Epub 2020 Aug 22.

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