Strain Report - Rat Genome Database

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Strain: SD-Fahem10Dlli-/-

Symbol: SD-Fahem10Dlli-/-
Strain: SD-Fahem10-/-
Substrain: Dlli
RGD ID: 14398828
Citation ID: RRID:RGD_14398828
Ontology ID: RS:0004711
Alleles: Fahem10Dlli-/-
Also Known As: fahd10/d10; SD-Fah^[em10Dlli-/-]
Type: mutant
Available Source: Not Available
Origination: East China Normal University, Shanghai, China.
Description: This strain was produced by injecting Sprague Dawley embryo with CRISP/Case9 system targeting the exon 2 of rat Fah gene. The resulting mutation is a 10-bp deletion in exon 2 caused premature stop in the Fah protein. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates
Genetic Status: Homozygous
Last Known Status: Unknown
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21138,548,830 - 138,571,599RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01146,713,663 - 146,736,339RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01147,640,316 - 147,662,920RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41140,851,975 - 140,876,187RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Cas9-nickase-mediated genome editing corrects hereditary tyrosinemia in rats. Shao Y, etal., J Biol Chem. 2018 May 4;293(18):6883-6892. doi: 10.1074/jbc.RA117.000347. Epub 2018 Mar 5.


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