Strain Report - Rat Genome Database

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Strain: SD-Fahem15Dlli-/-

Symbol: SD-Fahem15Dlli-/-
Strain: SD-Fahem15-/-
Substrain: Dlli
RGD ID: 14398825
Citation ID: RRID:RGD_14398825
Ontology ID: RS:0004710
Alleles: Fahem15Dlli-/-
Also Known As: Fah-/-; SD-Fah^[em15Dlli-/-]
Type: mutant
Available Source: Not Available
Origination: East China Normal University, Shanghai, China.
Description: This strain was produced by injecting Sprague Dawley embryo with CRISPR/Cas9 system targeting the exon 2 of rat Fah gene. The resulting mutation is line 15 with a frameshift deletion causing Fah null in homozygotes. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21138,548,830 - 138,571,599RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01146,713,663 - 146,736,339RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01147,640,316 - 147,662,920RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41140,851,975 - 140,876,187RGD_MAPPER_PIPELINERGSC3.4





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Efficient liver repopulation of transplanted hepatocyte prevents cirrhosis in a rat model of hereditary tyrosinemia type I. Zhang L, etal., Sci Rep. 2016 Aug 11;6:31460. doi: 10.1038/srep31460.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-05-02 SD-Fahem15Dlli-/-    SD-Fahem1Dlli-/-15    Symbol updated 68687 APPROVED
2019-05-02 SD-Fahem15Dlli-/-    SD-Fahem1Dlli-/-15    Symbol updated 68687 APPROVED