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Strain: SD-Cftrem1Sage-/-

Symbol: SD-Cftrem1Sage-/-
Strain: SD-Cftrem1-/Cftrem1-
Substrain: Sage
RGD ID: 14392815
Citation ID: RRID:RGD_14392815
Ontology ID: RS:0004681
Alleles: Cftrem1Sage
Also Known As: SD-Cftr^[em1Sage-/-]
Type: mutant
Available Source: inotiv
Origination: inotiv
Description: CFTR ZFN knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (Cftr), resulting in loss of protein expression. The homozygous mutant rats are produced by crossing the Cftr heterozygous rats.
Genetic Status: Homozygous
Last Known Status: Unknown (as of 2019-03-04)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2446,561,269 - 46,728,759RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0442,693,263 - 42,860,679RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0442,281,040 - 42,448,571RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4443,874,852 - 44,041,870RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat. Stalvey MS, etal., PLoS One. 2017 Nov 30;12(11):e0188497. doi: 10.1371/journal.pone.0188497. eCollection 2017.
2. Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats. Tuggle KL, etal., PLoS One. 2014 Mar 7;9(3):e91253. doi: 10.1371/journal.pone.0091253. eCollection 2014.


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