Strain Report - Rat Genome Database

Name: SD- Cftr em1Sage-/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Cftr^em1Sage-/-

Symbol:

SD-Cftr^em1Sage-/-

Strain:

SD-Cftr^em1-/Cftr^em1-

Substrain:

Sage

RGD ID:

14392815

Citation ID:

RRID:RGD_14392815

Ontology ID:

RS:0004681

Alleles:

Cftr^em1Sage

Type:

mutant

Source:

Horizon Discovery

Origin:

CFTR ZFN knockout rats possess a 16 bp deletion in exon 3 of the Cystic Fibrosis transmembrane conductance regulator (Cftr), resulting in loss of protein expression. The homozygous mutant rats are produced by crossing the Cftr heterozygous rats.

Genetic Status:

Homozygous

Last Known Status:

Unknown (as of 2019-03-04)

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	4	46,561,269 - 46,728,759	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	4	42,693,263 - 42,860,679	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	4	42,281,040 - 42,448,571	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	4	43,874,852 - 44,041,870	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

congenital bilateral absence of vas deferens (IMP)

cystic fibrosis (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal chloride level (IMP)

abnormal circulating protein level (IMP)

abnormal epiphyseal plate morphology (IMP)

abnormal nasal mucosa morphology (IMP)

abnormal small intestinal villus morphology (IMP)

abnormal tooth color (IMP)

abnormal trachea gland morphology (IMP)

abnormal tracheal cartilage morphology (IMP)

decreased body weight (IMP)

decreased circulating insulin-like growth factor I level (IMP)

decreased circulating serum albumin level (IMP)

decreased compact bone volume (IMP)

decreased T cell number (IMP)

decreased trabecular bone volume (IMP)

increased blood urea nitrogen level (IMP)

increased compact bone thickness (IMP)

increased neutrophil cell number (IMP)

short femur (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

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Clinical Measurement

nasal septum epithelium intracellular mucus area to basement membrane width ratio

trachea lumen circumference

trachea cartilage area

trachea cartilage area to trachea lumen circumference ratio

maximum trachea cartilage thickness

trachea epithelial layer thickness

trachea submucosal gland area

trachea submucosal gland area to trachea lumenal circumference ratio

trachea submucosal gland intracellular mucus area

trachea submucosal gland intracellular mucus area to total trachea submucosal gland area ratio

References

References - curated

#	Reference Title	Reference Citation
1.	Reduced bone length, growth plate thickness, bone content, and IGF-I as a model for poor growth in the CFTR-deficient rat.	Stalvey MS, etal., PLoS One. 2017 Nov 30;12(11):e0188497. doi: 10.1371/journal.pone.0188497. eCollection 2017.
2.	Characterization of defects in ion transport and tissue development in cystic fibrosis transmembrane conductance regulator (CFTR)-knockout rats.	Tuggle KL, etal., PLoS One. 2014 Mar 7;9(3):e91253. doi: 10.1371/journal.pone.0091253. eCollection 2014.

Region

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Cftrem1Sage-/-

Mammalian Phenotype

Related Phenotype Data for Term "SD-Cftrem1Sage-/-" (RS:0004681)

Strain: SD-Cftr^em1Sage-/-