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Strain: SD-Trpv1em1Sage-/-

Symbol: SD-Trpv1em1Sage-/-
Strain: SD-Trpv1em1-/ Trpv1em1-
Substrain: Sage
RGD ID: 13792701
Citation ID: RRID:RGD_13792701
Ontology ID: RS:0004629
Alleles: Trpv1em1Sage
Also Known As: TGRS5530 ; TRPV-/-; SD-Trpv1^[em1Sage-/-]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: These ZFN mutant rats were produced by injecting zinc finger nuclease targeting exon 13 of rat Trpv1 into Sprague Dawley embryos. A 2-bp (CA) frameshift deletion in exon 13 was created. Homozygous knockout rats exhibit complete loss of Trpv1 protein.
Genetic Status: Homozygous
Last Known Status: Cryopreserved Embryo (as of 2018-09-21)
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21057,851,428 - 57,876,513RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01059,799,123 - 59,824,208RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01059,538,296 - 59,563,441RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41060,109,656 - 60,134,939RGD_MAPPER_PIPELINERGSC3.4

Disease Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References - curated
# Reference Title Reference Citation
1. Transient Receptor Potential Vanilloid 1 Regulates Mitochondrial Membrane Potential and Myocardial Reperfusion Injury. Hurt CM, etal., J Am Heart Assoc. 2016 Sep 26;5(9). pii: JAHA.116.003774. doi: 10.1161/JAHA.116.003774.
2. Hypernatremia-induced vasopressin secretion is not altered in TRPV1-/- rats. Tucker AB and Stocker SD, Am J Physiol Regul Integr Comp Physiol. 2016 Sep 1;311(3):R451-6. doi: 10.1152/ajpregu.00483.2015. Epub 2016 Jun 22.


Additional Information