Strain Report - Rat Genome Database

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Strain: SD-Cd59em1Ask-/-

Symbol: SD-Cd59em1Ask-/-
Strain: SD-Cd59em1-/Cd59em1-
Substrain: Ask
Full Name: SD-Cd59em1-/Cd59em1-
RGD ID: 13792606
Citation ID: RRID:RGD_13792606
Ontology ID: RS:0004625
Alleles: Cd59em1Ask
Also Known As: SD-Cd59em1Ask-/-; SD-Cd59^[em1Ask]-/-]
Type: mutant
Available Source: Not Available
Origination: Cardiovascular Research Institute,University of California San Francisco, CA 94143-0521 USA
Description: The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2390,459,085 - 90,477,571RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0394,010,481 - 94,028,660RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03100,650,411 - 100,668,036RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4389,243,600 - 89,245,129RGD_MAPPER_PIPELINERGSC3.4





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Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G. Yao X and Verkman AS, Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9.

Region


Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-29 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-04-23 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-04-23 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-04-23 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-04-23 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-04-08 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-04-02 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-04-02 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-04-02 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-04-02 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-04-01 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-03-26 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-03-26 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-03-26 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-03-26 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-03-25 SD-Cd59em1Ask-/-  SD-Cd59em1Ask-/Cd59em1Ask-  SD-Cd59em1Ask-/-  SD-Cd59em1Ask-/Cd59em1Ask-  gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-03-22 SD-Cd59em1Ask-/-  SD-Cd59em1Ask-/Cd59em1Ask-  SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol and/or name change 68913 APPROVED
2019-01-28 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-01-22 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-01-22 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-01-22 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2019-01-22 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2019-01-14 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-01-08 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  Name updated 68913 APPROVED
2019-01-08 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  Name updated 68913 APPROVED
2019-01-08 SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  Name updated 68913 APPROVED
2019-01-08 SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  Symbol updated 68687 APPROVED
2019-01-07 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2019-01-04 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    Symbol updated 68687 APPROVED
2019-01-04 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    Symbol updated 68687 APPROVED
2018-10-12 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  Name updated 68913 APPROVED
2018-10-12 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59-em1-  Name updated 68913 APPROVED
2018-10-01 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED
2018-09-25 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2018-09-25 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2018-09-25 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Name updated 68913 APPROVED
2018-09-25 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-  SD-Cd59em1-/Cd59em1-  Symbol updated 68687 APPROVED
2018-09-24 SD-Cd59em1Ask-/-    SD-Cd59em1Ask-/-    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED