Strain Report - Rat Genome Database

Name: SD- Cd59 em1Ask -/-
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Cd59^em1Ask-/-

Symbol:

SD-Cd59^em1Ask-/-

Strain:

SD-Cd59^em1-/Cd59^em1-

Substrain:

Ask

Full Name:

SD-Cd59^em1-/Cd59^em1-

RGD ID:

13792606

Citation ID:

RRID:RGD_13792606

Ontology ID:

RS:0004625

Alleles:

Cd59^em1Ask

Previously known as:

SD-Cd59^em1Ask-/-

Type:

mutant

Source:

Cardiovascular Research Institute,University of California San Francisco, CA 94143-0521 USA

Origin:

The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants.

Genetic Status:

Homozygous

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	90,459,085 - 90,477,571	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	3	94,010,481 - 94,028,660	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	3	100,650,411 - 100,668,036	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	3	89,243,600 - 89,245,129	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

neuromyelitis optica (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased erythrocyte cell number (IMP)

increased red blood cell distribution width (IMP)

increased susceptibility to type III hypersensitivity reaction (IMP)

reticulocytosis (IMP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

Options:

View chart

Download data table

View expanded data table

Clinical Measurement

red blood cell count

blood hemoglobin level

white blood cell count

hematocrit

red blood cell distribution width-coefficient of variation

reticulocyte count to total red blood cell count ratio

References

References - curated

#	Reference Title	Reference Citation
1.	Marked central nervous system pathology in CD59 knockout rats following passive transfer of Neuromyelitis optica immunoglobulin G.	Yao X and Verkman AS, Acta Neuropathol Commun. 2017 Feb 17;5(1):15. doi: 10.1186/s40478-017-0417-9.

Region

Additional Information

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-29	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-04-23	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-04-23	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-04-23	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-04-23	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-04-08	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-04-02	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-04-02	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-04-02	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-04-02	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-04-01	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-03-26	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-03-26	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-03-26	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-03-26	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-03-25	SD-Cd59^em1Ask-/-	SD-Cd59^em1Ask-/Cd59^em1Ask-	SD-Cd59^em1Ask-/-	SD-Cd59^em1Ask-/Cd59^em1Ask-	gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-03-22	SD-Cd59^em1Ask-/-	SD-Cd59^em1Ask-/Cd59^em1Ask-	SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol and/or name change	68913	APPROVED
2019-01-28	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-01-22	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-01-22	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-01-22	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2019-01-22	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2019-01-14	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-01-08	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	Name updated	68913	APPROVED
2019-01-08	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	Name updated	68913	APPROVED
2019-01-08	SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	Name updated	68913	APPROVED
2019-01-08	SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	Symbol updated	68687	APPROVED
2019-01-07	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2019-01-04	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		Symbol updated	68687	APPROVED
2019-01-04	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		Symbol updated	68687	APPROVED
2018-10-12	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	Name updated	68913	APPROVED
2018-10-12	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59-^em1-	Name updated	68913	APPROVED
2018-10-01	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED
2018-09-25	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2018-09-25	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2018-09-25	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Name updated	68913	APPROVED
2018-09-25	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-	SD-Cd59^em1-/Cd59^em1-	Symbol updated	68687	APPROVED
2018-09-24	SD-Cd59^em1Ask-/-		SD-Cd59^em1Ask-/-		gene nomenclature is perpetuated to the strain symbol	2293819	APPROVED

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MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
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Strain: SD-Cd59em1Ask-/-

Mammalian Phenotype

Related Phenotype Data for Term "SD-Cd59em1Ask-/-" (RS:0004625)

Strain: SD-Cd59^em1Ask-/-