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Strain: WI-Oprl1m1Hubr-/-

Symbol: WI-Oprl1m1Hubr-/-
Strain: WI-Oprl1m1-/-
Substrain: Hubr
Full Name: NOPr knockout rat
RGD ID: 13792572
Citation ID: RRID:RGD_13792572
Ontology ID: RS:0004617
Alleles: Oprl1m1Hubr
Also Known As: oprl1â¿¿/â¿¿ rats; WI-Oprl1^[m1Hubr-/-]
Type: mutant
Available Source: Not Available
Origination: Hubrecht Laboratory, Utrecht, The Netherlands
Description: The original mutants were created by target-selected ENU-induced mutagenesis in a Brown Norway background. The animals were outcrossed for two generations on a Brown Norway background. they were subsequently backcrossed on a Wistar (Crl:WI) background for four generations. Backcrossings were performed to eliminate possible additional mutations induced by ENU-mutagenesis. Heterozygous oprl1+/- rats were crossed to generate the experimental animals. A C to G transversion at position 3657 in the oprl1 gene (ENSRNOG00000016768), resulting into a premature stop codon (TAC>TAG) in the third exon.NOPr is completely absent in homozygous mutants.
Genetic Status: Homozygous
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr83189,209,495 - 189,225,406RGD_MAPPER_PIPELINE
mRatBN7.23168,831,934 - 168,839,920RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.03177,223,779 - 177,231,663RGD_MAPPER_PIPELINERnor6.0
Rnor_5.03180,932,344 - 180,943,574RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.43170,869,862 - 170,873,417RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Visceral hypersensitivity in female but not in male serotonin transporter knockout rats. Galligan JJ, etal., Neurogastroenterol Motil. 2013 Jun;25(6):e373-81. doi: 10.1111/nmo.12133. Epub 2013 Apr 17.
2. Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in mu, delta and kappa opioid receptors. Homberg JR, etal., Neuroscience. 2009 Sep 29;163(1):308-15. doi: 10.1016/j.neuroscience.2009.06.021. Epub 2009 Jun 12.
3. Acute and subchronic antinociceptive effects of nociceptin/orphanin FQ receptor agonists infused by intrathecal route in rats. Micheli L, etal., Eur J Pharmacol. 2015 May 5;754:73-81. doi: 10.1016/j.ejphar.2015.02.020. Epub 2015 Feb 19.
4. Nociceptin/orphanin FQ receptor knockout rats: in vitro and in vivo studies. Rizzi A, etal., Neuropharmacology. 2011 Mar;60(4):572-9. doi: 10.1016/j.neuropharm.2010.12.010. Epub 2010 Dec 22.
5. Pharmacological blockade or genetic knockout of the NOP receptor potentiates the rewarding effect of morphine in rats. Rutten K, etal., Drug Alcohol Depend. 2011 Apr 1;114(2-3):253-6. doi: 10.1016/j.drugalcdep.2010.10.004. Epub 2010 Nov 20.

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