Strain Report - Rat Genome Database

Name: SD- Il2rg em1Ang
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Il2rg^em1Ang

Symbol:

SD-Il2rg^em1Ang

Strain:

SD-Il2rg^em1

Substrain:

Ang

RGD ID:

13628730

Citation ID:

RRID:RGD_13628730

Ontology ID:

RS:0004596

Alleles:

Il2rg^em1Ang

Previously known as:

line1.3

Type:

mutant

Source:

Centre de Recherche en Transplantation et Immunologie UMR1064, INSERM, University de Nantes, Nantes, France.

Origin:

TALEN targeting the 2nd exon of rat Il2rg gene was designed and mRNA coding these TALEN was microinjected into Crl:SD embyo.This strain carrying an 80 bp deletion generated a premature stop codon in the 3rd exon. No Il2rg protein was detected by western blot.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	X	66,398,441 - 66,398,520	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	X	71,168,483 - 71,168,562	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	X	72,017,856 - 72,021,516	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	X	89,342,055 - 89,345,715	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Immune Deficiency Disease (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

decreased bone marrow cell number (IMP)

decreased CD4-positive, alpha-beta T cell number (IMP)

decreased CD8-positive, alpha-beta T cell number (IMP)

decreased mature B cell number (IMP)

decreased NK cell number (IMP)

decreased T cell number (IMP)

decreased thymocyte number (IMP)

lymph node hypoplasia (IMP)

spleen hypoplasia (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Generation of immunodeficient rats with Rag1 and Il2rg gene deletions and human tissue grafting models.	Ménoret S, etal., Transplantation. 2018 Apr 24. doi: 10.1097/TP.0000000000002251.

Region

Allelic Variants

Name	Chromosome	Start Pos	End Pos	Reference Nucleotide	Variant Nucleotide	Variant Type	Assembly
Il2rgem1Ang-var1	chrX	66398441	66398520	AACCCACCTTCTCTTCTTCCTGTACTACCCCTCCCCCTTCTCATACCTATAGTGCATAGTGAGGTTGGTCGGCTGAGGCT	-	deletion	mRatBN7.2
Il2rgem1Ang-var1	chrX	71168483	71168562	AACCCACCTTCTCTTCTTCCTGTACTACCCCTCCCCCTTCTCATACCTATAGTGCATAGTGAGGTTGGTCGGCTGAGGCT	-	deletion	Rnor_6.0

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Il2rgem1Ang

Mammalian Phenotype

Strain: SD-Il2rg^em1Ang