Strain Report - Rat Genome Database

Name: SS-Chr 12 BN /Mcwi
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SS-Chr 12^BN/Mcwi
Symbol:	SS-Chr 12^BN/Mcwi
Strain:	SS-Chr 12^BN
Substrain:	Mcwi
RGD ID:	1358162
Citation ID:	RRID:RGD_1358162
Ontology ID:	RS:0000793
Also Known As:	SS-12BN/Mcwi; SS-Chr 12BN/Mcwi; SS-Chr 12^[BN]/Mcwi
Type:	consomic
Available Source:	Not Available
Origination:	PhysGen
Description:	A SS genomic background with a BN chromosome 12 introgressed.
Coat Color:	Albino
Last Known Status:	Live Animals

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Albuminuria (IAGP)

Experimental Mammary Neoplasms (IAGP)

hypertension (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

albuminuria (IAGP)

increased mammary adenocarcinoma incidence (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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Clinical Measurement

heart rate

left ventricular diastolic blood pressure

left ventricular systolic blood pressure

mean arterial blood pressure

body weight

body temperature

left ventricular developed pressure

red blood cell count

blood hemoglobin level

blood neutrophil count

blood lymphocyte count

blood monocyte count

blood eosinophil count

hematocrit

mean corpuscular volume

plasma anion gap

heart wet weight

heart weight to body weight ratio

lung dry weight to body weight ratio

heart right ventricle weight to left ventricle weight ratio

plasma renin activity level

minute ventilation

arterial blood flow rate

tidal volume

partial pressure of blood carbon dioxide (Pco2)

percent change in ventilation

respiration rate

mean corpuscular hemoglobin

mean corpuscular hemoglobin concentration

absolute change in partial pressure of blood carbon dioxide

absolute change in partial pressure of blood oxygen

absolute change in blood pH

serum total cholesterol level

total white blood cell count

serum total bilirubin level

blood pH

partial pressure of blood oxygen

serum bicarbonate level

serum chloride level

serum potassium level

serum sodium level

serum calcium level

percent change in respiration rate

percent change in tidal volume

plasma creatinine level

serum phosphate level

serum glucose level

serum albumin level

serum alanine aminotransferase activity level

serum alkaline phosphatase activity level

serum aspartate aminotransferase activity level

serum urea nitrogen level

serum total protein level

time to onset of heart contraction

time to peak heart contraction

heart contraction pressure

heart left ventricle infarction weight to total heart left ventricle weight ratio

absolute change in body temperature

calculated pulmonary vascular resistance normalized to body weight

FAPGG metabolism-surface area product

methylene blue metabolism-surface area product without auto-oxidation

methylene blue metabolism-surface area product after auto-oxidation

methylene blue to FAPGG metabolism-surface area product ratio

dose of methacholine at which pulmonary conductance is half its pretreatment value

fractional change in blood vessel diameter per unit change in intravascular pressure

concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (EC50)

logarithm of the concentration of phenylephrine at which the force of blood vessel contraction is half the maximum value (Log EC50)

concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (EC50)

logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)

maximum contractile force per wet weight of aorta

acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel

percent change in heart rate

percent change in arterial blood flow rate

percent change in left ventricular developed pressure

percent change in left ventricular systolic blood pressure

urine total protein excretion rate

urine albumin excretion rate

urine sodium excretion rate

urine potassium excretion rate

creatinine clearance

heart effluent lactate dehydrogenase activity level normalized to heart weight

artery wall thickness to artery inner diameter ratio

serum globulin level

References

References - curated

#	Reference Title	Reference Citation
1.	Identification of novel carcinogen-mediated mammary tumor susceptibility loci in the rat using the chromosome substitution technique.	Adamovic T, et al., Genes Chromosomes Cancer. 2010 Nov;49(11):1035-45.
2.	Genetic mapping of mammary tumor traits to rat chromosome 10 using a novel panel of consomic rats.	Adamovic T, etal., Cancer Genet Cytogenet. 2008 Oct;186(1):41-8.
3.	Identification of hypertension susceptibility loci on rat chromosome 12.	Flister MJ, etal., Hypertension. 2012 Oct;60(4):942-8. doi: 10.1161/HYPERTENSIONAHA.112.198200. Epub 2012 Aug 6.
4.	Sex-Specific Differences in Chromosome-Dependent Regulation of Vascular Reactivity in Female Consomic Rat Strains from a SS x BN Cross.	Kunert MP, etal., Am J Physiol Regul Integr Comp Physiol. 2008 May 28;.
5.	Consomic strategies to localize genomic regions related to vascular reactivity in the Dahl salt-sensitive rat.	Kunert MP, etal., Physiol Genomics. 2006 Aug 16;26(3):218-25. Epub 2006 Jun 13.
6.	Chromosome substitution reveals the genetic basis of Dahl salt-sensitive hypertension and renal disease.	Mattson DL, etal., Am J Physiol Renal Physiol. 2008 Sep;295(3):F837-42. Epub 2008 Jul 23.
7.	PhysGen Strains	PhysGen strains
8.	Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12.	Prisco SZ, etal., Am J Physiol Heart Circ Physiol. 2014 Oct 15;307(8):H1103-10. doi: 10.1152/ajpheart.00464.2014. Epub 2014 Aug 22.
9.	Refined Mapping of a Hypertension Susceptibility Locus on Rat Chromosome 12.	Prisco SZ, etal., Hypertension. 2014 Jul 7. pii: HYPERTENSIONAHA.114.03550.
10.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_drgs_chems	The aortic rings of animals on low-salt diet were less sensitive to phenylephrine as compared to the parental SS.	1598768
strain_other	The average weight of females is 183g and of males 277g.	629526
strain_reproduction	The average litter size is 9 pups and the average generation time is 53 days.	629526

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-12	SS-Chr 12^BN/Mcwi		SS-Chr 12^BN/Mcwi		Name updated	68913	APPROVED
2013-08-12	SS-Chr 12^BN/Mcwi		SS-Chr 12^BN/Mcwi		Name updated	68913	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SS-Chr 12BN/Mcwi

Mammalian Phenotype

Related Phenotype Data for Term "SS-Chr 12BN/Mcwi" (RS:0000793)

Strain: SS-Chr 12^BN/Mcwi