Strain Report - Rat Genome Database

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Strain: COP/CrCrl

Symbol: COP/CrCrl
Strain: COP
Substrain: CrCrl
RGD ID: 1358153
Citation ID: RRID:RGD_1358153
Ontology ID: RS:0000185
Previously known as: MDC-03-19; COP/CrCrlBR; Copenhagen rat
Type: inbred
Source: Charles River Laboratories
Origin: Inbred strain is from Curtis in 1921 at Columbia University Institute for Cancer Research. To National Cancer Institute Animal Production Program (Cr). To Charles River from the National Cancer Institute in 1998.
Genetic Markers: Hooded
Coat Color: White
Last Known Status: Unknown

Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
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References - curated
# Reference Title Reference Citation
1. Genetic determination of susceptibility to estrogen-induced mammary cancer in the ACI rat: mapping of Emca1 and Emca2 to chromosomes 5 and 18. Gould KA, etal., Genetics 2004 Dec;168(4):2113-25.
2. Rat strain specific attenuation of estrogen action in the anterior pituitary gland by dietary energy restriction. Harvell DM, etal., Endocrine 2003 Jul;21(2):175-83.
3. Rat strain-specific actions of 17beta-estradiol in the mammary gland: correlation between estrogen-induced lobuloalveolar hyperplasia and susceptibility to estrogen-induced mammary cancers. Harvell DM, etal., Proc Natl Acad Sci U S A 2000 Mar 14;97(6):2779-84.
4. Tissue-Specific Actions of the Ept1, Ept2, Ept6, and Ept9 Genetic Determinants of Responsiveness to Estrogens in the Female Rat. Kurz SG, etal., Endocrinology. 2008 Apr 17;.
5. Strains registered by Charles River Laboratories International, Inc. Personal communication with Charles River Laboratories
6. RGD Strain RSO annotation pipeline RGD Automated Pipelines
7. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
8. Susceptibility to estrogen-induced mammary cancer segregates as an incompletely dominant phenotype in reciprocal crosses between the ACI and Copenhagen rat strains. Shull JD, etal., Endocrinology 2001 Dec;142(12):5124-30.
9. Estrogen-induced tumorigenesis in the Copenhagen rat: disparate susceptibilities to development of prolactin-producing pituitary tumors and mammary carcinomas. Spady TJ, etal., Cancer Lett 1998 Feb 13;124(1):95-103.
10. Genetic bases of estrogen-induced pituitary growth in an intercross between the ACI and Copenhagen rat strains: dominant mendelian inheritance of the ACI phenotype. Spady TJ, etal., Endocrinology 1999 Jun;140(6):2828-35.
11. Genetic Bases of Estrogen-Induced Pituitary Tumorigenesis: Identification of Genetic Loci Determining Estrogen-Induced Pituitary Growth in Reciprocal Crosses between the ACI and Copenhagen Rat Strains. Strecker TE, etal., Genetics 2005 Jan 31;.


Strain QTL Data
Symbol Name Trait
Emca1 Estrogen-induced mammary cancer QTL 1 mammary gland integrity trait   (VT:0010552)    
Emca2 Estrogen-induced mammary cancer QTL 2 mammary gland integrity trait   (VT:0010552)    
Ept1 Estrogen-induced pituitary tumorigenesis QTL 1 pituitary gland mass   (VT:0010496)    
Ept10 Estrogen-induced pituitary tumorigenesis QTL 10 pituitary gland mass   (VT:0010496)    
Ept13 Estrogen-induced pituitary tumorigenesis QTL 13 pituitary gland mass   (VT:0010496)    
Ept2 Estrogen-induced pituitary tumorigenesis QTL 2 pituitary gland mass   (VT:0010496)    
Ept6 Estrogen-induced pituitary tumorigenesis QTL 6 pituitary gland mass   (VT:0010496)    
Ept9 Estrogen-induced pituitary tumorigenesis QTL 9 pituitary gland mass   (VT:0010496)    
Damaging Variants
Number of Damaging Variants
COP/CrCrl (MCW & UW) 1058
COP/CrCrl (MCW & UW) 1467
COP/CrCrl (MCW & UW) 3428

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Synthetic estrogen diethylstilbestrol (DES) induces pituitary growth in ACI and COP rats and their F1, F2 and backcross progeny. 1358974
strain_drgs_chems DES induces an increase in the circulating PRL in ACI males as compared to COP males. 1358974
strain_drgs_chems DES treatment on males for 12 weeks induced the development of PRL-producing pituitary tumors comprising of enlarged pituitary glands displaying lactotroph hyperplasia and associated hyperprolactinemia. 1358975
strain_drgs_chems Strain has decreased sensitivity to DES-induced pituitary growth. 1334449
strain_drgs_chems These females are relatively resistant to 17beta-estradiol induced mammary tumorigenesis. 1358956
strain_life_disease F1, F2 and backcross progeny of these rats with ACI show significantly prolonged latency for E2 induced mammary cancer. 1358956
strain_life_disease 17beta-estradiol stimulates mammary cell proliferation and lobuloalveolar hyperplasia. 1358963
strain_life_disease E2 induced atypical epithelial hyperplasia is not present in COP rats which is observed in ACI rats. 1358963
strain_other 12 weeks of E2 treatment in females exhibit an increase in pituitary weight and circulating PRL. 1358963