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Strain: BB.SHR-(D4Got41-Tacr1)/K

Symbol: BB.SHR-(D4Got41-Tacr1)/K
Strain: BB.SHR-(D4Got41-Tacr1)
Substrain: K
RGD ID: 1357980
Citation ID: RRID:RGD_1357980
Ontology ID: RS:0000063
Also Known As: BB.4S; NBRP Rat No: 0261; BB.SHR-(D4Got41-Tacr1)/K
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: Dept. of Laboratory Animal Science, University of Greifswald, Karlsburg, Germany
Description: Congenic BB.LL rats were established as speed-congenics by cross of BB/OK and SHR/Mol rats and repeated backcrossing onto BB/OK rats and marker-aided selection in 1997.
Coat Color: White
Inbred Generations: F12
Last Known Status: Cryopreserved Sperm
Research Usage Diabetes Obesity; Metabolism
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2461,697,658 - 115,089,733RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0460,439,127 - 113,416,139RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0460,179,409 - 178,095,041RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4460,262,965 - 116,780,394RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table


References

References - curated
# Reference Title Reference Citation
1. Phenotypic consequences after restoration of lymphopenia in the diabetes-prone BB/OK rat. Kloting I, etal., Biochem Biophys Res Commun 1997 Oct 9;239(1):106-10.
2. Alleles on rat chromosome 4 (D4Got41-Fabp1/Tacr1) regulate subphenotypes of obesity. Kloting N, etal., Obes Res 2005 Mar;13(3):589-95.
3. Phenotypic and genetic analyses of subcongenic BB.SHR rat lines shorten the region on chromosome 4 bearing gene(s) for underlying facets of metabolic syndrome. Kloting N, etal., Physiol Genomics 2004 Aug 11;18(3):325-30.
4. Congenic BB.SHR rat provides evidence for effects of a chromosome 4 segment (D4Mit6-Npy approximately 1 cm) on total serum and lipoprotein lipid concentration and composition after feeding a high-fat, high-cholesterol diet. Kovacs P, etal., Metabolism 2001 Apr;50(4):458-62.
5. Endocrine pancreas histology of congenic BB-rat strains with reduced diabetes incidence after genetic manipulation on chromosomes 4, 6 and X. Lucke S, etal., Autoimmunity 2003 May;36(3):143-9.
6. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
7. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D4Got41)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2461,697,658 - 61,697,820 (+)MAPPER
Rnor_6.0460,439,127 - 60,439,288NCBI
Rnor_5.0460,179,409 - 60,179,570UniSTS
RGSC_v3.4460,262,965 - 60,263,127RGD
RGSC_v3.4460,262,966 - 60,263,127UniSTS
RGSC_v3.1460,539,096 - 60,539,257RGD
Celera456,782,083 - 56,782,236UniSTS
RH 3.4 Map4383.6UniSTS
RH 3.4 Map4383.6RGD
RH 2.0 Map4430.3RGD

Flank 2 / 1 (Tacr1)
Rat AssemblyChrPosition (strand)Source
GRCr84116,478,617 - 116,647,492 (+)NCBI
mRatBN7.24114,920,844 - 115,089,733 (+)NCBI
mRatBN7.2 Ensembl4114,920,844 - 115,089,733 (+)Ensembl
UTH_Rnor_SHR_Utx4120,383,645 - 120,552,243 (+)NCBI
UTH_Rnor_SHRSP_BbbUtx_1.04116,158,843 - 116,327,453 (+)NCBI
UTH_Rnor_WKY_Bbb_1.04114,778,790 - 114,948,892 (+)NCBI
Rnor_6.04113,247,236 - 113,416,139 (+)NCBI
Rnor_6.0 Ensembl4113,247,795 - 113,414,504 (+)Ensembl
Rnor_5.04177,926,094 - 178,095,041 (+)NCBI
RGSC_v3.44116,610,595 - 116,780,394 (+)NCBI
RGSC_v3.14116,855,058 - 117,024,964 (+)NCBI
Celera4103,918,032 - 104,086,347 (+)NCBI
Cytogenetic Map4q34NCBI
Strain QTL Data
Symbol Name Trait
Bw52 Body weight QTL 52 body mass   (VT:0001259)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Animals are not hypertensive, but develop a incomplete metabolic syndrome with obesity, hyperleptinemia and dyslipidemia.About 70% of animals are prone to apoplectic stroke. 1357197
strain_life_disease Strain is normotensive but develops an incomplete metabolic syndrome including obesity, hyerleptinemia, and dyslipidemia. 1334440
strain_phys_biochem Strain shows significant elevation in serum leptin and AI levels. 1334440

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-15 BB.SHR-(D4Got41-Tacr1)/K    BB.SHR-(D4Got41-Tacr1)/K    Name updated 68913 APPROVED