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Strain Registration

Strain: CDS/Ygl

Symbol: CDS/Ygl
Strain: CDS
Substrain: Ygl
Full Name: Cohen diabetic-sensitive rat
RGD ID: 1357191
Citation ID: RRID:RGD_1357191
Ontology ID: RS:0000181
Also Known As: MDC-01-88; CDS/y; CDs/y
Type: inbred
Available Source: Not Available
Origination: Hebrew University Hospital and Hadassah-Hebrew Medical College, Jerusalem, Israel
Description: Cohen rats that had an oral tolerance test with blood glucose levels >180mg/dl were selected. More stringent criteria was set during the secondary inbreeding: rats with blood glucose levels >230mg/dl were selected. Brother and sister mating was carried on for 10 additional generations.
Last Known Status: Unknown





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Mammalian Phenotype

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References

References - curated
# Reference Title Reference Citation
1. GENDER-SPECIFIC GENETIC DISSECTION OF DIABETES IN A RODENT MODEL IDENTIFIES ICA1 AND NDUFA4 AS MAJOR CANDIDATE GENES. Barkalifa R, etal., Physiol Genomics. 2010 Jun 8.
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
4. The newly inbred cohen diabetic rat: a nonobese normolipidemic genetic model of diet-induced type 2 diabetes expressing sex differences. Weksler-Zangen S, etal., Diabetes 2001 Nov;50(11):2521-9.
5. A novel mutation in the NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 4 (Ndufa4) gene links mitochondrial dysfunction to the development of diabetes in a rodent model. Yagil C, etal., Dis Model Mech. 2018 Nov 20;11(11). pii: dmm.036699. doi: 10.1242/dmm.036699.
6. Metabolic and genomic dissection of diabetes in the Cohen rat. Yagil C, etal., Physiol Genomics. 2007 Apr 24;29(2):181-92. Epub 2007 Jan 9.
7. Three interacting genomic loci incorporating two novel mutations underlie the evolution of diet-induced diabetes. Yagil Y, etal., Mol Med. 2016 Jul 26;22. doi: 10.2119/molmed.2016.00114.
8. Unmasking of proteinuria in the course of genetic dissection of nonproteinuric diabetic nephropathy. Yagil Y, etal., Physiol Genomics. 2014 Jan 1;46(1):29-38. doi: 10.1152/physiolgenomics.00133.2013. Epub 2013 Nov 5.

Region

Strain QTL Data
Symbol Name Trait
Gluco32 Glucose level QTL 32 blood glucose amount   (VT:0000188)    
Gluco33 Glucose level QTL 33 blood glucose amount   (VT:0000188)    
Gluco34 Glucose level QTL 34 blood glucose amount   (VT:0000188)    
Gluco61 Glucose level QTL 61 blood glucose amount   (VT:0000188)    
Gluco62 Glucose level QTL 62 blood glucose amount   (VT:0000188)    
Gluco63 Glucose level QTL 63 blood glucose amount   (VT:0000188)    
Insul22 Insulin level QTL 22 blood insulin amount   (VT:0001560)    
Kidm43 Kidney mass QTL 43 kidney mass   (VT:0002707)    
Niddm71 Non-insulin dependent diabetes mellitus QTL 71 blood glucose amount   (VT:0000188)    
Niddm72 Non-insulin dependent diabetes mellitus QTL 72 blood glucose amount   (VT:0000188)    
Pancm3 Pancreatic morphology QTL 3 pancreas mass   (VT:0010144)    
Pancm4 Pancreatic morphology QTL 4 pancreas mass   (VT:0010144)    
Pur32 Proteinuria QTL 32 urine total protein amount   (VT:0000032)    
Rf60 Renal function QTL 60 blood creatinine amount   (VT:0005328)    
Rf61 Renal function QTL 61 blood creatinine amount   (VT:0005328)    
Rf62 Renal function QTL 62 blood urea nitrogen amount   (VT:0005265)    
Rf63 Renal function QTL 63 blood urea nitrogen amount   (VT:0005265)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Males that were fed the regular rat diet showed a 3 fold increase in their weight at 4-6 months whereas the males that were fed diabetogenic diet (high-sucrose low-copper) failed to thrive and doubles their weight in 4 months. Females did not show difference in growth curves irrespective of diet. 1342468
strain_characteristics They are sensitive to the diabetogenic diet. 1342468
strain_characteristics Females develop diabetes slower and show weaker metabloic phenotypes than males. 2326163
strain_life_disease 6-months old males that were fed the diabetogenic diet had low blood pressure. 1342468
strain_life_disease Males that were fed the diabetogenic diet showed increase in the blood glucose levels and became overtly diabetic. 1342468
strain_life_disease Basal fasting insulin levels were higher in these rats as compared to the CDR. 1342468
strain_life_disease Insulin levels were higher in animals that were fed diabetogenic diet than the ones fed regular diet. 1342468