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Strain Registration

Strain: RHA.Gunn-Ugt1a1j/N

Symbol: RHA.Gunn-Ugt1a1j/N
Strain: RHA.Gunn-Ugt1a1j
Substrain: N
RGD ID: 1357185
Citation ID: RRID:RGD_1357185
Ontology ID: RS:0000666
Also Known As: congenic inbred RHA/jj; RHA.Gunn-Ugt1a1j/N; RHA.Gunn-Ugt1a1^[j]/N
Type: congenic
Available Source: Not Available
Origination: Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institute of Health, Bethesda, MD, USA
Description: RHA/N rats were crossed with Gunn rats. F1 hybrids were intercrossed for 12 cycles while selecting for jaundice loci.
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection. Guha C, etal., Hepatology. 2002 Aug;36(2):354-62.
2. Differences in UDP-glucuronosyltransferase activities in congenic inbred rats homozygous and heterozygous for the jaundice locus. Mackenzie PI and Owens IS, Biochem Pharmacol 1983 Dec 15;32(24):3777-81.
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. Isolation of multiple normal and functionally defective forms of uridine diphosphate-glucuronosyltransferase from inbred Gunn rats. Roy Chowdhury N, etal., J Clin Invest 1987 Feb;79(2):327-34.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease These congenic animals lack the bilirubin UDP-glucunosyltransferase activity. 1354704
strain_life_disease Good genetic model for inheritable jaundice which is stable and reproducible. 1354704
strain_phys_biochem Five different isoforms have been isolated from the solubilized microsomal fractions from the liver; isoform I was functionally defective and was active toward 4-nitrophenol after the addition of DEN; isoform IV and V were inactive towards bilirubin. 1302863