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Strain Registration

Strain: BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw

Symbol: BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw
Strain: BBDR.BBDP-(D4Mit6-D4Mit24)
Substrain: Rhw
RGD ID: 1357174
Citation ID: RRID:RGD_1357174
Ontology ID: RS:0000075
Previously known as: BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw; DR.lyp; DR.lyp; BBDR.BBDP-(D4Mit6-D4Mit24)
Type: congenic
Source: Department of Medicine University of Washington, Seattle, Washington
Origin: S. Bieg and coworkers (1998) generated this congenic line in which diabetes and lymphopenia are controlled solely by Iddm 1. This strain was generated by nine cycles of cross-intercross breeding of diabetes-prone DP with DR BB rats. Iddm 1 in the BioBreeding (BB) rat designates the genomic region on rat Chromosome (Chr) 4 that harbors the gene causing peripheral T cell lymphopenia (Lyp) and diabetes. The average age of onset of diabetes was 85 ñ 53 days of age after the first and 67 ± 10 days of age after the 9th cycle. Lacks one C nucleotide at 478 position which causes a frameshift mutation in the ORF of exon 3 forming a significantly truncated protein.
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2476,647,384 - 78,882,945RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0477,307,388 - 79,575,658RGD_MAPPER_PIPELINERnor6.0
Rnor_5.04141,978,848 - 144,249,450RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4475,732,943 - 78,039,637RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Genetic isolation of iddm 1 on chromosome 4 in the biobreeding (BB) rat. Bieg S, etal., Mamm Genome 1998 Apr;9(4):324-6
2. Lymphopenia in the BB Rat Model of Type 1 Diabetes is Due to a Mutation in a Novel Immune-Associated Nucleotide (Ian)-Related Gene. MacMurray AJ, etal., Genome Res 2002 Jul;12(7):1029-39.
3. Genetic dissection of lymphopenia from autoimmunity by introgression of mutated Ian5 gene onto the F344 rat. Moralejo DH, etal., J Autoimmun 2003 Dec;21(4):315-24.
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. Sequence variation and expression of the Gimap gene family in the BB rat. Rutledge EA, etal., Exp Diabetes Res. 2009;2009:835650. Epub 2009 May 3.

Region

Position Markers

Flank 1 / 1 (D4Mit6)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2476,647,384 - 76,647,568 (+)MAPPER
Rnor_6.0477,307,388 - 77,307,571NCBI
Rnor_5.04141,978,848 - 141,979,031UniSTS
RGSC_v3.4475,732,943 - 75,733,127RGD
RGSC_v3.4475,732,944 - 75,733,127UniSTS
Celera471,452,122 - 71,452,305UniSTS
Cytogenetic Map4q24UniSTS

Flank 2 / 1 (D4Mit24)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2478,882,815 - 78,882,945 (+)MAPPER
Rnor_6.0479,575,532 - 79,575,658NCBI
Rnor_6.0479,559,378 - 79,559,505NCBI
Rnor_5.04144,235,275 - 144,235,402UniSTS
Rnor_5.04144,249,324 - 144,249,450UniSTS
RGSC_v3.4478,039,507 - 78,039,637RGD
RGSC_v3.4478,039,508 - 78,039,637UniSTS
RGSC_v3.1478,315,637 - 78,315,767RGD
Celera473,796,670 - 73,796,807UniSTS
RH 3.4 Map4500.0RGD
RH 3.4 Map4500.0UniSTS
RH 2.0 Map4554.5RGD
Cytogenetic Map4q24UniSTS

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other Lacks one C nucleotide at 478 position which causes a frameshift mutation in the ORF of exon 3 forming a significantly truncated protein. 619544

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-09-13 BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    Symbol updated 68687 APPROVED
2012-09-13 BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    Name updated 68913 APPROVED
2012-09-13 BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    Symbol updated 68687 APPROVED
2012-09-13 BBDR.BBDP-(D4Mit6-D4Mit24)/Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    Name updated 68913 APPROVED
2011-06-29 BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)    Symbol updated 68687 APPROVED
2011-06-29 BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)    Name updated 68913 APPROVED
2011-06-29 BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)    Symbol updated 68687 APPROVED
2011-06-29 BBDR.BBDP-(D4Mit6-D4Mit24)Rhw    BBDR.BBDP-(D4Mit6-D4Mit24)    Name updated 68913 APPROVED