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Strain Registration

Strain: BN/OrlIcoCrlf

Symbol: BN/OrlIcoCrlf
Strain: BN
Substrain: OrlIcoCrlf
RGD ID: 1354669
Citation ID: RRID:RGD_1354669
Ontology ID: RS:0000148
Type: inbred
Available Source: Charles River France
Origination: Charles River France
Description: Strain selected by Silvers and Billingham in 1958 after cross-breeding of histocompatible animals from a colony of mutants. These animals were then maintained in closed colony by H.D. King and P. Aptekman at the National Institutes of Health (NIH) (Bethesda, MD, USA). The strain was obtained by Microbiological Associates, Inc., Department of Laboratory Animals, Walkersville, Maryland, USA in 1969 and introduced into CNRS/CSEAL in Orleans, France in 1988. It was then transferred to Charles River Laboratories France in 1991.
Last Known Status: Unknown





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
Object SymbolSpeciesTermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
BN/OrlIcoCrlfRatBN/OrlIcoCrlf  IEA 7241799 RGD 

References

References - curated
# Reference Title Reference Citation
1. Mapping of genetic loci predisposing to hypertriglyceridaemia in the hereditary hypertriglyceridaemic rat: analysis of genetic association with related traits of the insulin resistance syndrome. Klimes I, etal., Diabetologia 2003 Mar;46(3):352-8.
2. Mapping of genetic determinants of the sympathoneural response to stress. Klimes I, etal., Physiol Genomics 2005 Jan 20;20(2):183-7. Epub 2004 Nov 16.
3. QTL mapping for traits associated with stress neuroendocrine reactivity in rats. Llamas B, etal., Mamm Genome 2005 Jul;16(7):505-15.
4. Gain of function mutation in the mineralocorticoid receptor of the Brown Norway rat. Marissal-Arvy N, etal., J Biol Chem 2004 Sep 17;279(38):39232-9. Epub 2004 Jul 12.
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS). Rudolf G, etal., Epilepsia 2004 Apr;45(4):301-8.

Region

Strain QTL Data
Symbol Name Trait
Bw28 Body weight QTL 28 body mass   (VT:0001259)    
Bw29 Body weight QTL 29 body mass   (VT:0001259)    
Foco1 Food consumption QTL 1 eating behavior trait   (VT:0001431)    
Foco2 Food consumption QTL 2 eating behavior trait   (VT:0001431)    
Gmadr1 Adrenal mass QTL 1 adrenal gland mass   (VT:0010420)    
Salc1 Saline consumption QTL 1 drinking behavior trait   (VT:0001422)    
Salc2 Saline consumption QTL 2 drinking behavior trait   (VT:0001422)    
Stl4 Serum triglyceride level QTL 4 blood triglyceride amount   (VT:0002644)    
Stl5 Serum triglyceride level QTL 5 blood triglyceride amount   (VT:0002644)    
Stl6 Serum triglyceride level QTL 6 blood triglyceride amount   (VT:0002644)    
Stresp14 Stress response QTL 14 blood renin amount   (VT:0003349)    
Stresp15 Stress response QTL 15 blood aldosterone amount   (VT:0005346)    
Stresp16 Stress response QTL 16 blood renin amount   (VT:0003349)    
Stresp17 Stress response QTL 17 blood aldosterone amount   (VT:0005346)    
Stresp18 Stress response QTL 18 thymus mass   (VT:0004954)    
Stresp19 Stress response QTL 19 blood renin amount   (VT:0003349)    
Stresp20 Stress response QTL 20 blood renin amount   (VT:0003349)    
Stresp21 Stress response QTL 21 thymus mass   (VT:0004954)    
Stresp22 Stress response QTL 22 thymus mass   (VT:0004954)    
Stresp6 Stress response QTL 6 blood norepinephrine amount   (VT:0005663)    
Stresp7 Stress response QTL 7 blood norepinephrine amount   (VT:0005663)    
Swd3 Spike wave discharge measurement QTL 3 brain electrophysiology trait   (VT:0010557)    
Swd4 Spike wave discharge measurement QTL 4 brain electrophysiology trait   (VT:0010557)    
Swd5 Spike wave discharge measurement QTL 5 brain electrophysiology trait   (VT:0010557)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Long-lived: estimated median life-span more than 24 months in males and more than 25 months in females 2308782
strain_drgs_chems Deoxycorticosterone (DOC) had no effect on these rats. 1302889
strain_drgs_chems GR-specific agonist (RU28362) was able to induce weight loss, thymus invoution, decreased food intake and decreased plasma transcortin concentration in the BN rats than in F344. 1302889
strain_other No weight loss was induced by adrenalectomy (ADX) during the first week and the growth rate was increased in the third week. 1302889
strain_reproduction Low fertility 2308782

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2010-09-24 BN/OrlIcoCrlf    BN/OrlCrlf    Symbol updated 68687 APPROVED
2010-09-24 BN/OrlIcoCrlf    BN/OrlCrlf    Name updated 68913 APPROVED
2010-09-24 BN/OrlIcoCrlf    BN/OrlCrlf    Symbol updated 68687 APPROVED
2010-09-24 BN/OrlIcoCrlf    BN/OrlCrlf    Name updated 68913 APPROVED