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Strain Registration

Strain: GK

Symbol: GK
Strain: GK
RGD ID: 13506737
Citation ID: RRID:RGD_13506737
Ontology ID: RS:0001299
Type: inbred
Available Source: Not Available
Description: The Goto-Kakizaki (GK) rat is a non-obese Wistar substrain which develops Type 2 diabetes mellitus early in life. The model was developed by Goto and Kakizaki at Tohoku University, Sendai, Japan in 1975. The GK line was established by repeated inbreeding from Wistar rats selected at the upper limit of normal distribution for glucose tolerance. Repeated selection of rats with tendency to lowest glucose tolerance resulted in clear-cut glucose intolerance after five generations.Until the end of 1980s, GK rats were initiated with breeding pairs in several places and also commercially available from Japanese breeders Charles River Japan, Yokohama, Oriental Yeast, Tokyo, Clea Japan Inc., Osaka (GK/Clea), Japan SLC, Shizuoka (GK/SLC), Takeda Lab Ltd., Osaka (GK/Taked), and from Taconic, USA (GK/Mol/Tac).
Last Known Status: Unknown





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Clinical Measurement
heart rate
systolic blood pressure
diastolic blood pressure
mean arterial blood pressure
body weight
plasma glucose level
blood glucose level
heart wet weight
heart weight to body weight ratio
plasma insulin level
blood glucose level area under curve (AUC)
serum insulin level
heart left ventricle weight to body weight ratio
plasma estradiol level
plasma total cholesterol level
plasma low density lipoprotein cholesterol level
logarithm of the concentration of acetylcholine at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
logarithm of the concentration of sodium nitroprusside at which the reduction in force during dilation of a blood vessel is half the maximum value (Log EC50)
acetylcholine-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
sodium nitroprusside-induced blood vessel dilation expressed as percent reduction of the force generated in a pre-constricted blood vessel
plasma leptin level
heart right ventricle weight to body weight ratio
pancreatic islet insulin release measurement
pancreatic islet insulin level
mesenteric artery phosphorylated eNOS level to total eNOS level ratio
aorta wall phosphorylated eNOS level to total eNOS level ratio
serum fructosamine level
water intake drink rate to body weight ratio
heart left ventricle infarction area to total heart left ventricle area ratio
plasma insulin level to plasma glucose level ratio
soleus muscle weight
soleus muscle weight to body weight ratio
capillary number to soleus muscle fiber number ratio
plasma glucagon-like peptide 1 level
plasma gastric inhibitory polypeptide level
number of spontaneous locomotor movements per unit time

References

References - curated
# Reference Title Reference Citation
1. The cardiovascular effects of salidroside in the Goto-Kakizaki diabetic rat model. Alameddine A, etal., J Physiol Pharmacol. 2015 Apr;66(2):249-57.
2. Beta-cell insensitivity to glucose in the GK rat, a spontaneous nonobese model for type II diabetes. Portha B, etal., Diabetes. 1991 Apr;40(4):486-91.
3. The GK rat: a prototype for the study of non-overweight type 2 diabetes. Portha B, etal., Methods Mol Biol. 2012;933:125-59. doi: 10.1007/978-1-62703-068-7_9.
4. The rat STSL locus: characterization, chromosomal assignment, and genetic variations in sitosterolemic hypertensive rats. Yu H, etal., BMC Cardiovasc Disord 2003 Jun 3;3(1):4.

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