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Strain: SS.ZUC-Leprfa-/-/Slc

Symbol: SS.ZUC-Leprfa-/-/Slc
Strain: SS.ZUC-Leprfa-/-
Substrain: Slc
RGD ID: 13432148
Citation ID: RRID:RGD_13432148
Ontology ID: RS:0004550
Alleles: Leprfa
Also Known As: DS/obese; SS.ZUC-Leprfa-/-/Slc; SS.ZUC-Lepr^[fa-/-]/Slc
Type: congenic
Available Source: Not Available
Description: SS.ZUC-Leprfa/Slc rats were generated as the result of an initial mating of a male Zucker rat (Japan SLC) heterozygous for the fa allele of Lepr with a female DahlS/JrSeac rat (Seac, Japan), followed by multiple rounds of backcrossing of the resulting progeny to the SS strain.
Last Known Status: Unknown
Research Usage Diabetes Obesity





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Clinical Measurement
heart rate
systolic blood pressure
body weight
blood total cholesterol level
blood high density lipoprotein cholesterol level
blood low density lipoprotein cholesterol level
serum creatinine level
ejection fraction
heart posterior wall thickness
heart left ventricle posterior wall thickness
serum insulin level
serum triglyceride level
serum high density lipoprotein cholesterol level
serum low density lipoprotein cholesterol level
serum total cholesterol level
serum glucose level
serum free fatty acids level
blood alanine aminotransferase activity level
serum alanine aminotransferase activity level
blood aspartate aminotransferase activity level
serum aspartate aminotransferase activity level
serum urea nitrogen level
urine protein level
left ventricular end-diastolic blood pressure
urine total protein level
serum leptin level
heart left ventricle end-diastolic diameter
heart left ventricle fractional shortening
heart ventricle septal wall thickness
heart left ventricle relative wall thickness
calculated heart left ventricle weight
heart weight to tibia length ratio
both kidneys wet weight to tibia length ratio
epididymal fat pad weight to tibia length ratio
creatinine clearance to body weight ratio
heart isovolumetric relaxation time
tibia straight segment length
time constant of left ventricular pressure decay
creatinine clearance to total kidney weight ratio
E wave deceleration time
myocardial performance index
heart left ventricle weight to tibia length ratio
E/A wave ratio
retroperitoneal fat pad weight to tibia length ratio
inguinal fat pad weight to tibia length ratio
heart left ventricular end-diastolic blood pressure to heart left ventricular end-diastolic diameter ratio
liver weight to tibia length ratio
pancreas weight to tibia length
single kidney weight to tibia length ratio
heart left atrium weight to tibia length ratio
heart left ventricle weight to right ventricle weight ratio
serum low density lipoprotein cholesterol to high density lipoprotein cholesterol ratio
mesenteric fat pad weight to tibia length ratio
ratio of survivors of metabolic syndrome to total study population during a period of time

References

References - curated
# Reference Title Reference Citation
1. Characterization of a new animal model of metabolic syndrome: the DahlS.Z-Lepr(fa)/Lepr(fa) rat. Hattori T, etal., Nutr Diabetes. 2011 Jan 31;1:e1. doi: 10.1038/nutd.2010.1.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Leprfa-var1 chr5 116389200 116389200 A C point_mutation mRatBN7.2
Leprfa-var1 chr5 120597857 120597857 A C point_mutation Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-09-21 SS.ZUC-Leprfa-/-/Slc    SS.ZUC-Leprfa/fa/Slc    Symbol updated 68687 APPROVED
2017-09-21 SS.ZUC-Leprfa-/-/Slc    SS.ZUC-Leprfa/fa/Slc    Symbol updated 68687 APPROVED