Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: F344-Tg(NPHS2-HBEGF)Wig

Symbol: F344-Tg(NPHS2-HBEGF)Wig
Strain: F344-Tg(NPHS2-HBEGF)
Substrain: Wig
RGD ID: 1302921
Citation ID: RRID:RGD_1302921
Ontology ID: RS:0000487
Also Known As: F344-Tg(DTR)C354Wig
Type: transgenic
Available Source: Not Available
Origination: Division of Nephrology, Department of Internal Medicine, University of MIchigan, Ann Habor, Michigan
Description: hDTR (HBEGF) cDNA was inserted at the 3' of the 2.5 kb human podocin (NPHS2) promoter. This transgenic construct was released by XbaI/HindIII digestion and injected into the pronuclei of fertilized eggs.
Last Known Status: Unknown





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. RGD Strain RSO annotation pipeline RGD Automated Pipelines
2. Podocyte depletion causes glomerulosclerosis: diphtheria toxin-induced podocyte depletion in rats expressing human diphtheria toxin receptor transgene. Wharram BL, etal., J Am Soc Nephrol 2005 Oct;16(10):2941-52. Epub 2005 Aug 17.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_life_disease Injection of 50 microgram/kg of diphtheria toxin caused depletion of podocytes from the glomerulus which causes renal failure. 1556472
strain_other These animals have HDTR expressed in the outer aspect of the glomerular capillary walls. 1556472

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-04-26 F344-Tg(NPHS2-HBEGF)Wig    F344-Tg(DTR)C354Wig    Symbol updated 68687 APPROVED
2019-04-26 F344-Tg(NPHS2-HBEGF)Wig    F344-Tg(DTR)C354Wig    Symbol updated 68687 APPROVED