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Strain Registration

Strain: LEXF5/Stm

Symbol: LEXF5/Stm
Strain: LEXF5
Substrain: Stm
RGD ID: 1302723
Citation ID: RRID:RGD_1302723
Ontology ID: RS:0000546
Also Known As: NBRP Rat No: 0112; MDC-02-62
Type: recombinant_inbred
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This strain is derived from systematic breeding of the F2 generation between LE/Stm and F344/DuCrlj.
Inbred Generations: F45
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Diabetes Obesity; Cancer





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

Phenotype Values via PhenoMiner     Click to see Annotation Detail View
Options:  View chart  |  Download data table  |  View expanded data table

Clinical Measurement
heart rate
systolic blood pressure
body weight
body temperature
red blood cell count
blood hemoglobin level
white blood cell count
platelet count
hematocrit
mean corpuscular volume
plasma glucose level
plasma aspartate aminotransferase activity level
plasma alanine aminotransferase activity level
plasma alkaline phosphatase activity level
plasma total protein level
plasma albumin level
plasma phosphate level
plasma chloride level
plasma sodium level
plasma potassium level
heart wet weight
heart weight to body weight ratio
both kidneys wet weight
lung wet weight
urine potassium level
urine sodium level
brain weight to body weight ratio
both kidneys wet weight as percentage of body weight
liver weight as percentage of body weight
spleen weight to body weight ratio
brain wet weight
lung weight to body weight ratio
liver wet weight
both adrenal glands wet weight
spleen wet weight
both testes wet weight
activated partial thromboplastin time
prothrombin time
timed urine volume
mean corpuscular hemoglobin
mean corpuscular hemoglobin concentration
blood basophil count to total leukocyte count ratio
blood eosinophil count to total leukocyte count ratio
blood lymphocyte count to total leukocyte count ratio
blood monocyte count to total leukocyte count ratio
total plasma calcium level
urine chloride level
plasma creatinine level
plasma triglyceride level
plasma total cholesterol level
plasma urea nitrogen level
both adrenal glands weight to body weight ratio
plasma high density lipoprotein cholesterol level
plasma low density lipoprotein cholesterol level
both testes wet weight to body weight ratio
percentage of study population developing leukemia during a period of time
urine sodium excretion rate to body weight ratio
post-insult time to onset of leukemia
post-insult time to onset of T-cell lymphoma
percentage of study population developing T-cell lymphomas during a period of time
timed urine volume to body weight ratio
urine chloride excretion rate to body weight ratio
urine potassium excretion rate to body weight ratio
plasma total bilirubin level
blood segmented neutrophil count to total leukocyte count ratio
blood band neutrophil count to total leukocyte count ratio
non-specified leukocyte count to total leukocyte count ratio
plasma albumin to plasma total protein ratio

References

References - curated
# Reference Title Reference Citation
1. Propylnitrosourea-induced T-lymphomas in LEXF RI strains of rats: genetic analysis. Lu LM, etal., Br J Cancer 1999 May;80(5-6):855-61.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
5. The LEXF: a new set of rat recombinant inbred strains between LE/Stm and F344. Shisa H, etal., Mamm Genome 1997 May;8(5):324-7.
6. Evaluation of LEXF/FXLE rat recombinant inbred strains for the genetic dissection of complex traits. Voigt B, etal., Physiol Genomics. 2007 Nov 27;.

Region

Strain Samples in RGD with Damaging Variants (Polyphen)
AssemblySample 
mRatBN7.2 LEXF5/Stm (2019NG) View Damaging Variants


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_drgs_chems Oral administration of propylnitrosourea (PNU) induced 89.5% leukemia and 15% T-lymphoma incidence in these rats. 619600
strain_other D12Mit1 locus was heterozygous. 628402
strain_reproduction Good breeding performance. 628402

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-09 LEXF5/Stm    LEXF5/Stm    Name updated 68913 APPROVED