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Strain Registration

Strain: F344.OLETF-(D8Rat58-D8Mgh17)/Tj

Symbol: F344.OLETF-(D8Rat58-D8Mgh17)/Tj
Strain: F344.OLETF-(D8Rat58-D8Mgh17)
Substrain: Tj
RGD ID: 1302713
Citation ID: RRID:RGD_1302713
Ontology ID: RS:0000296
Previously known as: F.O-Nidd3/of; NBRP Rat No: 0061; F344.OLETF-(D8Rat54-D8Mgh12)/Tj; F344.OLETF-(D8Rat58-D8Mgh17)/Tj
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred.
Inbred Generations: F10
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2846,008,836 - 46,008,974RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0850,007,641 - 50,007,776RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0821,850,030 - 48,631,820RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4819,796,514 - 48,675,424RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. OLETF allele of hyperglycemic QTL Nidd3/of is dominant. Kose H, etal., Exp Anim. 2008 Apr;57(2):135-8.
2. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D8Rat54)
Rat AssemblyChrPosition (strand)Source
Rnor_5.0821,850,030 - 21,850,200NCBI
RGSC_v3.4819,796,514 - 19,796,683RGD
RGSC_v3.1819,796,514 - 19,796,683RGD
RH 3.4 Map8181.0UniSTS
RH 3.4 Map8181.0RGD
SHRSP x BN Map814.26RGD
SHRSP x BN Map814.26UniSTS

Flank 2 / 1 (D8Mgh12)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2846,008,836 - 46,008,974 (+)MAPPER
Rnor_6.0850,007,641 - 50,007,776NCBI
Rnor_5.0848,631,685 - 48,631,820UniSTS
RGSC_v3.4848,675,288 - 48,675,424RGD
RGSC_v3.4848,675,289 - 48,675,424UniSTS
RGSC_v3.1848,684,054 - 48,684,190RGD
Celera845,591,619 - 45,591,754UniSTS
RH 3.4 Map8467.0UniSTS
RH 3.4 Map8467.0RGD
RH 2.0 Map8370.0RGD
Cytogenetic Map8q22UniSTS

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics hyperglycemia after glucose challenge in the OGTT assay 625760
strain_reproduction Good breeding performance 625760