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Strain Registration

Strain: F344.OLETF-(D5Rat32-D5Rat26)/Tj

Symbol: F344.OLETF-(D5Rat32-D5Rat26)/Tj
Strain: F344.OLETF-(D5Rat32-D5Rat26)
Substrain: Tj
RGD ID: 1302706
Citation ID: RRID:RGD_1302706
Ontology ID: RS:0000294
Also Known As: F.O-Nidd5/of; F344.OLETF-(D5Rat32-D5Rat26)/Tj
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Description: Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.37.4 cM segment of the OLETF genome was transferred.
Inbred Generations: F10
Last Known Status: Unknown
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.25113,558,156 - 132,686,472RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.05117,554,114 - 138,123,957RGD_MAPPER_PIPELINERnor6.0
Rnor_5.05121,495,621 - 141,933,383RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.45119,332,868 - 139,659,574RGD_MAPPER_PIPELINERGSC3.4






References

References - curated
# Reference Title Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines

Region

Position Markers

Flank 1 / 1 (D5Rat32)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25132,686,313 - 132,686,472 (+)MAPPER
Rnor_6.05138,123,799 - 138,123,957NCBI
Rnor_5.05141,933,225 - 141,933,383UniSTS
RGSC_v3.45139,659,416 - 139,659,574UniSTS
RGSC_v3.45139,659,415 - 139,659,574RGD
RGSC_v3.15139,664,642 - 139,664,800RGD
Celera5131,213,176 - 131,213,338UniSTS
RH 3.4 Map5868.7RGD
RH 3.4 Map5868.7UniSTS
RH 2.0 Map5864.3RGD
SHRSP x BN Map570.6499RGD

Flank 2 / 1 (D5Rat26)
Rat AssemblyChrPosition (strand)Source
mRatBN7.25113,558,156 - 113,558,310 (+)MAPPER
Rnor_6.05117,554,114 - 117,554,267NCBI
Rnor_5.05121,495,621 - 121,495,774UniSTS
RGSC_v3.45119,333,064 - 119,333,217UniSTS
RGSC_v3.45119,332,868 - 119,333,229RGD
RGSC_v3.15119,338,290 - 119,338,443RGD
Celera5112,120,988 - 112,121,159UniSTS
RH 3.4 Map5795.0RGD
RH 3.4 Map5795.0UniSTS
SHRSP x BN Map561.5499UniSTS
SHRSP x BN Map561.5499RGD
FHH x ACI Map558.41RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics hyperglycemia after glucose challenge in the OGTT assay 625760
strain_life_disease Not different from F344 rat in any of the observed diabetic phenotypes. 625760
strain_reproduction Good breeding performance 625760

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-01-19 F344.OLETF-(D5Rat32-D5Rat26)/Tj    F344.OLETF-(D5Rat32-D5Rat26)/Tj    Name updated 68913 APPROVED
2015-01-19 F344.OLETF-(D5Rat32-D5Rat26)/Tj    F344.OLETF-(D5Rat32-D5Rat26)/Tj    Name updated 68913 APPROVED