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Strain Registration

Strain: F344.OLETF-(D14Rat23-D14Rat12)/Tj

Symbol: F344.OLETF-(D14Rat23-D14Rat12)/Tj
Strain: F344.OLETF-(D14Rat23-D14Rat12)
Substrain: Tj
RGD ID: 1302661
Citation ID: RRID:RGD_1302661
Ontology ID: RS:0000289
Previously known as: F.O-Nidd2/of;F344 background OLETF Congenic; F.O-Nidd2/of; NBRP Rat No: 0058; F344.OLETF-(D14Rat23-D14Rat12)/Tj
Type: congenic
Source: National BioResource Project for the Rat in Japan
Origin: Male OLETF was crossed with female F344. F1 were backcrossed to female F344 for 5 generations. Microsatellite-based genotyping was performed to select the best male that had the best OLETF donor genome. Once the region was fixed the resultant congenic strain was maintained by brother-sister mating.29.5 cM segment from the centromere of chr 14 of the OLETF genome was transferred.
Inbred Generations: F9
Last Known Status: Cryopreserved Embryo
Research Usage Diabetes Obesity
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2141,217,606 - 39,153,750RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0142,227,825 - 61,783,215RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0142,222,207 - 61,886,417RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4141,764,386 - 41,707,592RGD_MAPPER_PIPELINERGSC3.4





References

References - curated
# Reference Title Reference Citation
1. Examination of OLETF-derived non-insulin-dependent diabetes mellitus QTL by construction of a series of congenic rats. Kose H, etal., Mamm Genome 2002 Oct;13(10):558-62.
2. Epistasis between hyperglycemic QTLs revealed in a double congenic of the OLETF rat. Kose H, etal., Mamm Genome. 2007 Aug;18(8):609-15. Epub 2007 Aug 21.
3. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
4. RGD Strain RSO annotation pipeline RGD Automated Pipelines
5. New animal models reveal that coenzyme Q2 (Coq2) and placenta-specific 8 (Plac8) are candidate genes for the onset of type 2 diabetes associated with obesity in rats. Sasaki D, etal., Mamm Genome. 2015 Dec;26(11-12):619-29. doi: 10.1007/s00335-015-9597-4. Epub 2015 Aug 22.

Region

Position Markers

Flank 1 / 1 (D14Rat23)
Rat AssemblyChrPosition (strand)Source
mRatBN7.2141,217,606 - 1,217,776 (+)MAPPER
Rnor_6.0142,227,825 - 2,227,992NCBI
Rnor_5.0142,222,207 - 2,222,374UniSTS
RGSC_v3.4141,764,386 - 1,764,554RGD
RGSC_v3.4141,764,387 - 1,764,554UniSTS
RGSC_v3.1141,764,386 - 1,764,554RGD
Celera141,256,962 - 1,257,129UniSTS
RH 2.0 Map140.0RGD
FHH x ACI Map141.33RGD

Flank 2 / 1 (D14Rat12)
Rat AssemblyChrPosition (strand)Source
mRatBN7.21439,153,581 - 39,153,750 (-)MAPPER
Rnor_6.01461,783,047 - 61,783,215NCBI
Rnor_5.01461,886,249 - 61,886,417UniSTS
RGSC_v3.41441,707,423 - 41,707,592RGD
RGSC_v3.41441,707,424 - 41,707,592UniSTS
RGSC_v3.11441,709,814 - 41,709,983RGD
Celera1438,346,383 - 38,346,551UniSTS
RH 2.0 Map14500.7RGD
SHRSP x BN Map1427.1799RGD

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics hyperglycemia after glucose challenge in the OGTT assay 625760
strain_reproduction Good breeding performance 625760

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-08 F344.OLETF-(D14Rat23-D14Rat12)/Tj    F344.OLETF-(D14Rat23-D14Rat12)/Tj    Name updated 68913 APPROVED
2012-05-08 F344.OLETF-(D14Rat23-D14Rat12)/Tj    F344.OLETF-(D14Rat23-D14Rat12)/Tj    Name updated 68913 APPROVED