Strain Report - Rat Genome Database

Name: WKY.SHRSP-( D1Wox29-D1Arb21 )/Izm
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Symbol:

WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Strain:

WKY.SHRSP-(D1Wox29-D1Arb21)

Substrain:

Izm

RGD ID:

1302636

Citation ID:

RRID:RGD_1302636

Ontology ID:

RS:0001054

Previously known as:

Wpch1.0; WKYpch1.0; NBRP Rat No: 0174; WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Type:

congenic

Source:

National BioResource Project for the Rat in Japan

Origin:

This congenic strain contains an SHRSP/Izm chromsome 1 segment containing a blood pressure QTL transferred to a WKY/Izm background

Last Known Status:

Cryopreserved Embryo

Research Usage

Cardio Hypertension

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	123,350,408 - 182,418,476	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	1	130,779,148 - 199,254,774	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	1	131,822,204 - 206,277,202	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	1	124,614,679 - 187,092,492	RGD_MAPPER_PIPELINE	RGSC3.4

Congenic Strains

WKY.SHRSP-(D1Wox29-D1Arb21)(Bcl2-D13Mgh7)/Izm

WKY.SHRSP-(D1Wox29-D1Arb21)(D9Mit6-D9Wox4)/Izm

WKY.SHRSP-(D1Wox29-D1Arb21)/IzmDmcr

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

hypertension (IAGP)

Stress-Induced Hypertension (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal renal sympathetic nerve activity (IAGP)

abnormal response of heart to induced stress (IAGP)

abnormal sensory capabilities/reflexes/nociception (IAGP)

abnormal sympathetic nervous system physiology (IAGP)

decreased noradrenaline level (IAGP)

decreased renal vascular resistance (IAGP)

decreased susceptibility to hypertension (IAGP)

hypertension (IAGP)

increased circulating noradrenaline level (IAGP)

increased heart rate (IAGP)

increased heart weight (IAGP)

increased kidney weight (IAGP)

increased mean systemic arterial blood pressure (IAGP)

increased renal plasma flow rate (IAGP)

increased renal sympathetic nerve activity (IAGP)

increased systemic arterial blood pressure (IAGP)

increased systemic arterial diastolic blood pressure (IAGP)

increased systemic arterial systolic blood pressure (IAGP)

increased urine adrenaline level (IAGP)

increased urine dopamine level (IAGP)

increased urine noradrenaline level (IAGP)

increased urine sodium level (IAGP)

Phenotype Values via PhenoMiner Click to see Annotation Detail View

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References

References - curated

#	Reference Title	Reference Citation
1.	Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus.	Cui ZH, etal., Clin Exp Pharmacol Physiol 2003 Jul;30(7):464-9.
2.	Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure.	Cui ZH, etal., J Hypertens 2004 Nov;22(11):2103-9.
3.	Relation of Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 to Hyperactivity of Rostralventrolateral Medulla.	Iigaya K, etal., Hypertension. 2008 Dec 1.
4.	Strains registered by the National Bio Resource Project for the Rat in Japan	Personal Communication with NBRP
5.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines
6.	Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1.	Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
7.	SYMPATHETIC REGULATION OF RENAL FUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS CONGENIC FOR CHROMOSOME 1 BLOOD PRESSURE QUANTITATIVE TRAIT LOCI.	Wang T, etal., Clin Exp Pharmacol Physiol. 2008 Jun 18;.
8.	Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus.	Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
9.	A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat.	Xiao B, etal., J Hypertens. 2010 Nov 8.
10.	Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats.	Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
11.	Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats.	Yao H, etal., Physiol Genomics. 2007 Feb 27;.

Region

Position Markers

Flank 1 / 1 (D1Wox29)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	123,350,408 - 123,350,581 (+)	MAPPER
Rnor_6.0	1	130,779,148 - 130,779,320	NCBI
Rnor_5.0	1	131,822,204 - 131,822,376	UniSTS
RGSC_v3.4	1	124,614,679 - 124,614,852	RGD
RGSC_v3.4	1	124,614,680 - 124,614,852	UniSTS
RGSC_v3.1	1	124,693,023 - 124,693,195	RGD
Celera	1	115,524,239 - 115,524,411	UniSTS
RH 3.4 Map	1	1458.6	RGD
RH 3.4 Map	1	1458.6	UniSTS

Flank 2 / 1 (D1Arb21)

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	182,418,219 - 182,418,476 (+)	MAPPER
Rnor_6.0	1	199,254,518 - 199,254,774	NCBI
Rnor_5.0	1	206,276,946 - 206,277,202	UniSTS
RGSC_v3.4	1	187,092,235 - 187,092,492	RGD
RGSC_v3.4	1	187,092,236 - 187,092,492	UniSTS
RGSC_v3.1	1	187,242,116 - 187,242,373	RGD
Celera	1	180,069,264 - 180,069,520	UniSTS
FHH x ACI Map	1	85.51	UniSTS
FHH x ACI Map	1	85.51	RGD
Cytogenetic Map	1	q36	UniSTS

Strain QTL Data

Symbol	Name	Trait
Cstrr1	Cold stress response QTL 1	catecholamine amount (VT:0010543)
Stresp23	Stress response QTL 23	kidney sympathetic nerve activity (VT:0004050)

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_phys_biochem	significant increase in urinary norepinephrine, vanillylmandelic acid, and blood pressure compared to WKY animals was observed	1302892
strain_phys_biochem	displays increased urinary excretion of norepinephrine (NE) and vanillylmandelic acid, increased plasma NE levels, and increased blood pressure in response to cold stress at levels greater than those observed in the parental WKY strain under cold stress	1302892
strain_phys_biochem	After air-jet stress shows a significant increase in renal sympathetic nerve activity and mean arterial pressure compared with WKY strain.	1578503
strain_phys_biochem	Basal membrane potential of rostral ventrolateral medulla (RVLM) neurons was less than that of WKY/Izm	2302408
strain_phys_biochem	Depolarization of RVLM neurons in response to angiotensin II was larger than that of WKY/Izm	2302408

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-05-10	WKY.SHRSP-(D1Wox29-D1Arb21)/Izm		WKY.SHRSP-(D1Wox29-D1Arb21)/Izm		Name updated	68913	APPROVED
2012-05-10	WKY.SHRSP-(D1Wox29-D1Arb21)/Izm		WKY.SHRSP-(D1Wox29-D1Arb21)/Izm		Name updated	68913	APPROVED

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Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Mammalian Phenotype

Related Phenotype Data for Term "WKY.SHRSP-(D1Wox29-D1Arb21)/Izm" (RS:0001054)