Strain Report - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Strain Registration

Strain: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm

Symbol: WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
Strain: WKY.SHRSP-(D1Wox29-D1Arb21)
Substrain: Izm
RGD ID: 1302636
Citation ID: RRID:RGD_1302636
Ontology ID: RS:0001054
Also Known As: Wpch1.0; WKYpch1.0; NBRP Rat No: 0174; WKY.SHRSP-(D1Wox29-D1Arb21)/Izm
Type: congenic
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This congenic strain contains an SHRSP/Izm chromsome 1 segment containing a blood pressure QTL transferred to a WKY/Izm background
Last Known Status: Cryopreserved Embryo
Research Usage Cardio Hypertension
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81132,760,429 - 191,848,948RGD_MAPPER_PIPELINE
mRatBN7.21123,350,408 - 182,418,476RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01130,779,148 - 199,254,774RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01131,822,204 - 206,277,202RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41124,614,679 - 187,092,492RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Exaggerated response to restraint stress in rats congenic for the chromosome 1 blood pressure quantitative trait locus. Cui ZH, etal., Clin Exp Pharmacol Physiol 2003 Jul;30(7):464-9.
2. Exaggerated response to cold stress in a congenic strain for the quantitative trait locus for blood pressure. Cui ZH, etal., J Hypertens 2004 Nov;22(11):2103-9.
3. Relation of Blood Pressure Quantitative Trait Locus on Rat Chromosome 1 to Hyperactivity of Rostralventrolateral Medulla. Iigaya K, etal., Hypertension. 2008 Dec 1.
4. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
5. RGD Strain RSO annotation pipeline RGD Automated Pipelines
6. Enhanced sympathetic control of renal function in rats congenic for the hypertension-related region on chromosome 1. Wang T, etal., Clin Exp Pharmacol Physiol. 2005 Dec;32(12):1055-60.
7. SYMPATHETIC REGULATION OF RENAL FUNCTION IN STROKE-PRONE SPONTANEOUSLY HYPERTENSIVE RATS CONGENIC FOR CHROMOSOME 1 BLOOD PRESSURE QUANTITATIVE TRAIT LOCI. Wang T, etal., Clin Exp Pharmacol Physiol. 2008 Jun 18;.
8. Sympathetic regulation of the renal functions in rats reciprocally congenic for chromosome 1 blood pressure quantitative trait locus. Wang T, etal., Hypertens Res. 2008 Mar;31(3):561-8.
9. A 1.8-Mbp fragment on chromosome 1 affects sympathetic response to stress: evaluation in reciprocal congenic strains between stroke-prone spontaneously hypertensive rat and Wistar-Kyoto rat. Xiao B, etal., J Hypertens. 2010 Nov 8.
10. Sympathetic hyperreactivity to air-jet stress in the chromosome 1 blood pressure quantitative trait locus congenic rats. Yamazato M, etal., Am J Physiol Regul Integr Comp Physiol. 2006 Mar;290(3):R709-14. Epub 2005 Oct 20.
11. Congenic removal of a QTL for blood pressure attenuates infarct size produced by middle cerebral artery occlusion in hypertensive rats. Yao H, etal., Physiol Genomics. 2007 Feb 27;.

Region

Position Markers

Flank 1 / 1 (D1Wox29)
Rat AssemblyChrPosition (strand)Source
GRCr81132,760,429 - 132,760,602 (+)Marker Load Pipeline
mRatBN7.21123,350,408 - 123,350,581 (+)MAPPER
Rnor_6.01130,779,148 - 130,779,320NCBI
Rnor_5.01131,822,204 - 131,822,376UniSTS
RGSC_v3.41124,614,680 - 124,614,852UniSTS
RGSC_v3.41124,614,679 - 124,614,852RGD
RGSC_v3.11124,693,023 - 124,693,195RGD
Celera1115,524,239 - 115,524,411UniSTS
RH 3.4 Map11458.6RGD
RH 3.4 Map11458.6UniSTS

Flank 2 / 1 (D1Arb21)
Rat AssemblyChrPosition (strand)Source
GRCr81191,848,691 - 191,848,948 (+)Marker Load Pipeline
mRatBN7.21182,418,219 - 182,418,476 (+)MAPPER
Rnor_6.01199,254,518 - 199,254,774NCBI
Rnor_5.01206,276,946 - 206,277,202UniSTS
RGSC_v3.41187,092,236 - 187,092,492UniSTS
RGSC_v3.41187,092,235 - 187,092,492RGD
RGSC_v3.11187,242,116 - 187,242,373RGD
Celera1180,069,264 - 180,069,520UniSTS
FHH x ACI Map185.51UniSTS
FHH x ACI Map185.51RGD
Cytogenetic Map1q36UniSTS
Strain QTL Data
Symbol Name Trait
Cstrr1 Cold stress response QTL 1 catecholamine amount   (VT:0010543)    
Stresp23 Stress response QTL 23 kidney sympathetic nerve activity   (VT:0004050)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_phys_biochem displays increased urinary excretion of norepinephrine (NE) and vanillylmandelic acid, increased plasma NE levels, and increased blood pressure in response to cold stress at levels greater than those observed in the parental WKY strain under cold stress 1302892
strain_phys_biochem After air-jet stress shows a significant increase in renal sympathetic nerve activity and mean arterial pressure compared with WKY strain. 1578503
strain_phys_biochem Basal membrane potential of rostral ventrolateral medulla (RVLM) neurons was less than that of WKY/Izm 2302408
strain_phys_biochem Depolarization of RVLM neurons in response to angiotensin II was larger than that of WKY/Izm 2302408
strain_phys_biochem significant increase in urinary norepinephrine, vanillylmandelic acid, and blood pressure compared to WKY animals was observed 1302892

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2012-05-10 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED
2012-05-10 WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    WKY.SHRSP-(D1Wox29-D1Arb21)/Izm    Name updated 68913 APPROVED