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Strain: KMI/Tky

Symbol: KMI/Tky
Strain: KMI
Substrain: Tky
Full Name: miniature rat ishikawa
RGD ID: 1302610
Citation ID: RRID:RGD_1302610
Ontology ID: RS:0000417
Alleles: Prkg2
Previously known as: NBRP Rat No: 0029; Komeda miniature rat Ishikawa
Type: segregating_inbred
Source: National BioResource Project for the Rat in Japan
Origin: Miniature Rat Ishikawa derived from a breeding colony of Wistar rats at the Ishikawa Animal Laboratory (Saitama). Introduced to Tokyo Medical College.
Coat Color: Albino
Inbred Generations: F42
Last Known Status: Live Animals; Cryopreserved Embryo; Cryopreserved Sperm
Research Usage Osteosis

Disease Annotations     Click to see Annotation Detail View
Dwarfism  (IAGP)


References - curated
# Reference Title Reference Citation
1. Cyclic GMP-dependent protein kinase II is a molecular switch from proliferation to hypertrophic differentiation of chondrocytes. Chikuda H, etal., Genes Dev. 2004 Oct 1;18(19):2418-29. doi: 10.1101/gad.1224204.
2. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
3. RGD Strain RSO annotation pipeline RGD Automated Pipelines
4. [Initial characterization of a new miniature animal model in the rat: studies on anatomy, pituitary hormones and GH mRNA in miniature rat Ishikawa] Serizawa N Nippon Naibunpi Gakkai Zasshi 1993 Jan 20;69(1):33-45.
5. Phenotypic characterization of the Komeda miniature rat Ishikawa, an animal model of dwarfism caused by a mutation in Prkg2. Tsuchida A, etal., Comp Med. 2008 Dec;58(6):560-7.


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_characteristics Experimental model for pituitary miniaturism with an autosomal recessive mode of inheritance. Body growth in MRI was retarded in 56% and 71% of normal control rats for males and females, respectively. 1302451
strain_reproduction Heterozygous female and homozygous male are selected to cross by the phenotype. 1302451