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Strain Registration

Strain: SPRD-Anks6PKD/Rrrc

Symbol: SPRD-Anks6PKD/Rrrc
Strain: SPRD-Anks6PKD
Substrain: Rrrc
RGD ID: 1302377
Citation ID: RRID:RRRC_00046
Ontology ID: RS:0000782
Alleles: Anks6PKD
Also Known As: SPRD-Pkdr1/Rrrc; SPRD-Pkdr1/Rrrc; SPRD-Anks6/Rrrc; SPRD-Anks6PKD/Rrrc; SPRD-Anks6^[PKD]/Rrrc
Type: mutant
Available Source: Rat Resource and Research Center
Origination: Rat Resource and Research Center
Description: From outbred Han:SPRD (Sprague-Dawley rats) from Zentralinstitut furVersuchstierkunde, Hannover. This strains carries the Pkdr1 (Anks6) mutation that causes autosomal dominant polycystic kidney disease. The strain was transferred from Dr. Jared Grantham, University of Kansas Medical Center to the Rat Resource and Research Center in 2002.
Genetic Markers: cy/+
Coat Color: albino
Inbred Generations: F20
Last Known Status: Cryopreserved Embryo; Cryopreserved Sperm (as of 2017-03-07)
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8566,104,770 - 66,146,186RGD_MAPPER_PIPELINE
mRatBN7.2561,309,183 - 61,350,596RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0562,642,974 - 62,684,387RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0567,163,440 - 67,204,853RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4563,633,540 - 63,674,953RGD_MAPPER_PIPELINERGSC3.4





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Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Data registered by the Rat Resource & Research Center Personal Communication with Rat Resource & Research Center
2. RGD Strain RSO annotation pipeline RGD Automated Pipelines
3. Characterization of the Han:SPRD rat model for hereditary polycystic kidney disease. Schafer K, etal., Kidney Int 1994 Jul;46(1):134-52.

Region


Additional Information

RGD Curation Notes
Note Type Note Reference
strain_anatomy Homozygous animals have severely enlarged kidneys. 1300446
strain_characteristics Homozygous animals have enlarged cystic kidneys and die by 4 weeks of age. Heterozygous animals have a slowly progressive polycystic kidney disease in which males are more severely affected than females. 1300446
strain_reproduction Average gestation period is 22 days with an average of 10 pups per litter. 1300446

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-03-13 SPRD-Anks6PKD/Rrrc    SPRD-Anks6 PKD/Rrrc    Symbol updated 68687 APPROVED
2018-03-13 SPRD-Anks6PKD/Rrrc    SPRD-Anks6 PKD/Rrrc    Symbol updated 68687 APPROVED
2017-03-07 SPRD-Anks6 PKD/Rrrc    SPRD-Anks6/Rrrc    Symbol updated 68687 APPROVED
2017-03-07 SPRD-Anks6 PKD/Rrrc    SPRD-Anks6/Rrrc    Symbol updated 68687 APPROVED
2012-04-18 SPRD-Anks6/Rrrc    SPRD-Anks6/Rrrc    Name updated 68913 APPROVED
2008-06-16 SPRD-Anks6/Rrrc    SPRD-Pkdr1/Rrrc    gene nomenclature is perpetuated to the strain symbol 2293819 APPROVED

Database Acc Id Source(s)
RRRC RRRC:00046 RGD