Strain Report - Rat Genome Database

Name: SDDIO/Rrrc
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SDDIO/Rrrc
Symbol:	SDDIO/Rrrc
Strain:	SDDIO
Substrain:	Rrrc
RGD ID:	1302372
Citation ID:	RRID:RRRC_00044
Ontology ID:	RS:0000701
Type:	inbred
Source:	Rat Resource and Research Center
Origin:	This strain was made by inbreeding SD rats selected for an obese phenotype when fed a high fat diet.
Coat Color:	albino
Inbred Generations:	F20
Last Known Status:	Cryopreserved Embryo; Cryopreserved Sperm

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

obesity (IAGP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal dentate gyrus morphology (IAGP)

abnormal energy homeostasis (IAGP)

abnormal lipid oxidation (IAGP)

abnormal spatial reference memory (IAGP)

decreased neuronal precursor cell number (IAGP)

increased body fat mass (IAGP)

increased body weight (IAGP)

increased circulating glucose level (IAGP)

increased circulating insulin level (IAGP)

increased circulating leptin level (IAGP)

increased food intake (IAGP)

increased liver weight (IAGP)

increased retroperitoneal fat pad weight (IAGP)

increased susceptibility to diet-induced obesity (IAGP)

increased urine noradrenaline level (IAGP)

oxidative stress (IAGP)

References

References - curated

#	Reference Title	Reference Citation
1.	Cognitive differences between Sprague-Dawley rats selectively bred for sensitivity or resistance to diet induced obesity.	Gurung S, etal., Behav Brain Res. 2016 Sep 15;311:122-130. doi: 10.1016/j.bbr.2016.05.018. Epub 2016 May 9.
2.	Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats.	Levin BE, etal., Am J Physiol 1997 Aug;273(2 Pt 2):R725-30.
3.	Data registered by the Rat Resource & Research Center	Personal Communication with Rat Resource & Research Center
4.	RGD Strain RSO annotation pipeline	RGD Automated Pipelines

Region

Additional Information

RGD Curation Notes

Note Type	Note	Reference
strain_characteristics	Obesity when fed a high fat diet.	1302371
strain_life_disease	These are obese animals.	1302371
strain_reproduction	The average number of pups produced per litter is less than seen with outbred SD rats and ranges from 4-8 pups per litter.	1302371

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2012-04-18	SDDIO/Rrrc		SDDIO/Rrrc		Name updated	68913	APPROVED
2012-04-18	SDDIO/Rrrc		SDDIO/Rrrc		Name updated	68913	APPROVED

External Database Links

Database	Acc Id	Source(s)
RRRC	RRRC:00044	RGD

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SDDIO/Rrrc

Mammalian Phenotype