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Strain Registration

Strain: LEW/NHsd

Symbol: LEW/NHsd
Strain: LEW
Substrain: NHsd
RGD ID: 1298093
Citation ID: RRID:RGD_1298093
Ontology ID: RS:0000521
Previously known as: MDC-03-06
Type: inbred
Source: Envigo
Origin: Descended from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. Maintained at Harlan-Sprague Dawley (Indianapolis, Indiana) .
Last Known Status: Unknown





Experimental Data Annotations    Click to see Annotation Detail View

Rat Strain
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
LEW/NHsd  IEA 7241799 RGD 

Vertebrate Trait
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
blood corticosterone amount  EXP 737981 RGD 
femur mineral mass  EXP 1578307 RGD 
femur morphology trait  EXP 1549683; 1578307 RGD 
femur strength trait  EXP 1549683; 1578307 RGD 
femur width  EXP 1578307 RGD 
kidney glomerulus integrity trait  EXP 2293335 RGD 
life span trait  EXP 619627; 2313695 RGD 
lumbar vertebra strength trait  EXP 1549683 RGD 
urine protein amount  EXP 2293335 RGD 
uvea integrity trait  EXP 2296064 RGD 


References

References - curated
# Reference Title Reference Citation
1. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Aitman TJ, etal., Nature. 2006 Feb 16;439(7078):851-5.
2. Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength. Alam I, etal., Bone. 2006 Feb 2;.
3. Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and lewis rats. Alam I, etal., J Bone Miner Res 2005 Sep;20(9):1589-96. Epub 2005 May 23.
4. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
5. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
6. Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kantachuvesiri S, etal., Kidney Int 1999 Aug;56(2):414-20.
7. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
8. Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
9. Common genetic determinants of uveitis shared with other autoimmune disorders. Mattapallil MJ, etal., J Immunol. 2008 May 15;180(10):6751-9.
10. Genomic regions controlling corticosterone levels in rats. Potenza MN, etal., Biol Psychiatry 2004 Mar 15;55(6):634-41.
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
13. The spontaneously hypertensive rat model of ADHD - The importance of selecting the appropriate reference strain. Sagvolden T, etal., Neuropharmacology. 2009 Aug 19.

Region

Strain QTL Data
Symbol Name Trait
Bmd10 Bone mineral density QTL 10 femur mineral mass   (VT:0010011)    
Bmd11 Bone mineral density QTL 11 femur mineral mass   (VT:0010011)    
Bmd12 Bone mineral density QTL 12 femur mineral mass   (VT:0010011)    
Bmd13 Bone mineral density QTL 13 femur mineral mass   (VT:0010011)    
Bmd14 Bone mineral density QTL 14 femur mineral mass   (VT:0010011)    
Bmd15 Bone mineral density QTL 15 femur mineral mass   (VT:0010011)    
Bmd16 Bone mineral density QTL 16 femur mineral mass   (VT:0010011)    
Bmd17 Bone mineral density QTL 17 femur mineral mass   (VT:0010011)    
Bmd18 Bone mineral density QTL 18 femur mineral mass   (VT:0010011)    
Bmd6 Bone mineral density QTL 6 femur mineral mass   (VT:0010011)    
Bmd7 Bone mineral density QTL 7 femur mineral mass   (VT:0010011)    
Bmd8 Bone mineral density QTL 8 femur mineral mass   (VT:0010011)    
Bmd9 Bone mineral QTL density 9 femur mineral mass   (VT:0010011)    
Bp342 Blood pressure QTL 342 life span trait   (VT:0005372)    
Bp343 Blood pressure QTL 343 life span trait   (VT:0005372)    
Bss1 Bone structure and strength QTL 1 femur strength trait   (VT:0010010)    
Bss10 Bone structure and strength QTL 10 femur morphology trait   (VT:0000559)    
Bss105 Bone structure and strength QTL 105 femur strength trait   (VT:0010010)    
Bss106 Bone structure and strength QTL 106 femur strength trait   (VT:0010010)    
Bss107 Bone structure and strength QTL 107 femur strength trait   (VT:0010010)    
Bss108 Bone structure and strength QTL 108 femur strength trait   (VT:0010010)    
Bss109 Bone structure and strength QTL 109 femur strength trait   (VT:0010010)    
Bss11 Bone structure and strength QTL 11 femur morphology trait   (VT:0000559)    
Bss110 Bone structure and strength QTL 1 femur strength trait   (VT:0010010)    
Bss111 Bone structure and strength QTL 111 femur morphology trait   (VT:0000559)    
Bss112 Bone structure and strength QTL 112 femur morphology trait   (VT:0000559)    
Bss12 Bone structure and strength QTL 12 femur morphology trait   (VT:0000559)    
Bss13 Bone structure and strength QTL 13 femur strength trait   (VT:0010010)    
Bss14 Bone structure and strength QTL 14 femur morphology trait   (VT:0000559)    
Bss15 Bone structure and strength QTL 15 femur width   (VT:1000666)    
Bss16 Bone structure and strength QTL 16 femur morphology trait   (VT:0000559)    
Bss17 Bone structure and strength QTL 17 femur morphology trait   (VT:0000559)    
Bss18 Bone structure and strength QTL 18 femur width   (VT:1000666)    
Bss19 Bone structure and strength QTL 19 femur morphology trait   (VT:0000559)    
Bss2 Bone structure and strength QTL 2 femur strength trait   (VT:0010010)    
Bss20 Bone structure and strength QTL 20 femur morphology trait   (VT:0000559)    
Bss21 Bone structure and strength QTL 21 femur morphology trait   (VT:0000559)    
Bss3 Bone structure and strength QTL 3 femur morphology trait   (VT:0000559)    
Bss4 Bone structure and strength QTL 4 femur strength trait   (VT:0010010)    
Bss5 Bone structure and strength QTL 5 femur strength trait   (VT:0010010)    
Bss6 Bone structure and strength QTL 6 lumbar vertebra strength trait   (VT:0010574)    
Bss7 Bone structure and strength QTL 7 femur strength trait   (VT:0010010)    
Bss8 Bone structure and strength QTL 8 lumbar vertebra strength trait   (VT:0010574)    
Bss9 Bone structure and strength QTL 9 femur morphology trait   (VT:0000559)    
Eau4 Experimental allergic uveoretinitis QTL 4 uvea integrity trait   (VT:0010551)    
Eau5 Experimental allergic uveoretinitis QTL 5 uvea integrity trait   (VT:0010551)    
Eau6 Experimental allergic uveoretinitis QTL 6 uvea integrity trait   (VT:0010551)    
Eau7 Experimental allergic uveoretinitis QTL 7 uvea integrity trait   (VT:0010551)    
Eau8 Experimental allergic uveoretinitis QTL 8 uvea integrity trait   (VT:0010551)    
Eau9 Experimental allergic uveoretinitis QTL 9 uvea integrity trait   (VT:0010551)    
Glom15 Glomerulus QTL 15 kidney glomerulus integrity trait   (VT:0010546)    
Glom16 Glomerulus QTL 16 kidney glomerulus integrity trait   (VT:0010546)    
Glom22 Glomerulus QTL 22 urine protein amount   (VT:0005160)    
Glom23 Glomerulus QTL 23 urine protein amount   (VT:0005160)    
Glom24 Glomerulus QTL 24 kidney glomerulus integrity trait   (VT:0010546)    
Glom25 Glomerulus QTL 25 urine protein amount   (VT:0005160)    
Glom26 Glomerulus QTL 26 urine protein amount   (VT:0005160)    
Stresp4 Stress response QTL 4 blood corticosterone amount   (VT:0005345)    
Stresp5 Stress response QTL 5 blood corticosterone amount   (VT:0005345)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-25 LEW/NHsd    LEW/NHsd    Name updated 68913 APPROVED
2014-09-25 LEW/NHsd    LEW/NHsd    Name updated 68913 APPROVED