Strain Report - Rat Genome Database

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Strain: LEW/NHsd

Symbol: LEW/NHsd
Strain: LEW
Substrain: NHsd
RGD ID: 1298093
Citation ID: RRID:RGD_1298093
Ontology ID: RS:0000521
Also Known As: MDC-03-06
Type: inbred
Available Source: Envigo
Description: Descended from a nucleus colony obtained from the National Institutes of Health, Bethesda, Maryland. Maintained at Harlan-Sprague Dawley (Indianapolis, Indiana) .
Last Known Status: Unknown





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Mammalian Phenotype

References

References - curated
# Reference Title Reference Citation
1. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Aitman TJ, etal., Nature. 2006 Feb 16;439(7078):851-5.
2. Identification of a quantitative trait locus on rat chromosome 4 that is strongly linked to femoral neck structure and strength. Alam I, etal., Bone. 2006 Feb 2;.
3. Whole-genome scan for linkage to bone strength and structure in inbred Fischer 344 and lewis rats. Alam I, etal., J Bone Miner Res 2005 Sep;20(9):1589-96. Epub 2005 May 23.
4. Resistance to myocardial ischemia in five rat strains: is there a genetic component of cardioprotection? Baker JE, etal., Am J Physiol Heart Circ Physiol 2000 Apr;278(4):H1395-400.
5. Combining distinctive and novel loci doubles BP reduction, reverses diastolic dysfunction and mitigates LV hypertrophy. Crespo K, etal., J Hypertens. 2013 May;31(5):927-35. doi: 10.1097/HJH.0b013e32835edc7e.
6. Genetic mapping of modifier loci affecting malignant hypertension in TGRmRen2 rats. Kantachuvesiri S, etal., Kidney Int 1999 Aug;56(2):414-20.
7. Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment. Klemcke HG, etal., Shock. 2008 Jun;29(6):748-53.
8. Angiotensin-converting enzyme is a modifier of hypertensive end organ damage. Liu X, etal., J Biol Chem. 2009 Jun 5;284(23):15564-72. Epub 2009 Mar 23.
9. Common genetic determinants of uveitis shared with other autoimmune disorders. Mattapallil MJ, etal., J Immunol. 2008 May 15;180(10):6751-9.
10. Genomic regions controlling corticosterone levels in rats. Potenza MN, etal., Biol Psychiatry 2004 Mar 15;55(6):634-41.
11. RGD Strain RSO annotation pipeline RGD Automated Pipelines
12. SNP and haplotype mapping for genetic analysis in the rat. Saar K, etal., Nat Genet. 2008 May;40(5):560-6.
13. The spontaneously hypertensive rat model of ADHD - The importance of selecting the appropriate reference strain. Sagvolden T, etal., Neuropharmacology. 2009 Aug 19.
14. Gene expression in accumbens GABA neurons from inbred rats with different drug-taking behavior. Sharp BM, etal., Genes Brain Behav. 2011 Oct;10(7):778-88. doi: 10.1111/j.1601-183X.2011.00716.x. Epub 2011 Aug 1.

Region

Strain QTL Data
Symbol Name Trait
Bmd10 Bone mineral density QTL 10 femur mineral mass   (VT:0010011)    
Bmd11 Bone mineral density QTL 11 femur mineral mass   (VT:0010011)    
Bmd12 Bone mineral density QTL 12 femur mineral mass   (VT:0010011)    
Bmd13 Bone mineral density QTL 13 femur mineral mass   (VT:0010011)    
Bmd14 Bone mineral density QTL 14 femur mineral mass   (VT:0010011)    
Bmd15 Bone mineral density QTL 15 femur mineral mass   (VT:0010011)    
Bmd16 Bone mineral density QTL 16 femur mineral mass   (VT:0010011)    
Bmd17 Bone mineral density QTL 17 femur mineral mass   (VT:0010011)    
Bmd18 Bone mineral density QTL 18 femur mineral mass   (VT:0010011)    
Bmd6 Bone mineral density QTL 6 femur mineral mass   (VT:0010011)    
Bmd7 Bone mineral density QTL 7 femur mineral mass   (VT:0010011)    
Bmd8 Bone mineral density QTL 8 femur mineral mass   (VT:0010011)    
Bmd9 Bone mineral QTL density 9 femur mineral mass   (VT:0010011)    
Bp342 Blood pressure QTL 342 life span trait   (VT:0005372)    
Bp343 Blood pressure QTL 343 life span trait   (VT:0005372)    
Bss1 Bone structure and strength QTL 1 femur strength trait   (VT:0010010)    
Bss10 Bone structure and strength QTL 10 femur morphology trait   (VT:0000559)    
Bss105 Bone structure and strength QTL 105 femur strength trait   (VT:0010010)    
Bss106 Bone structure and strength QTL 106 femur strength trait   (VT:0010010)    
Bss107 Bone structure and strength QTL 107 femur strength trait   (VT:0010010)    
Bss108 Bone structure and strength QTL 108 femur strength trait   (VT:0010010)    
Bss109 Bone structure and strength QTL 109 femur strength trait   (VT:0010010)    
Bss11 Bone structure and strength QTL 11 femur morphology trait   (VT:0000559)    
Bss110 Bone structure and strength QTL 1 femur strength trait   (VT:0010010)    
Bss111 Bone structure and strength QTL 111 femur morphology trait   (VT:0000559)    
Bss112 Bone structure and strength QTL 112 femur morphology trait   (VT:0000559)    
Bss12 Bone structure and strength QTL 12 femur morphology trait   (VT:0000559)    
Bss13 Bone structure and strength QTL 13 femur strength trait   (VT:0010010)    
Bss14 Bone structure and strength QTL 14 femur morphology trait   (VT:0000559)    
Bss15 Bone structure and strength QTL 15 femur width   (VT:1000666)    
Bss16 Bone structure and strength QTL 16 femur morphology trait   (VT:0000559)    
Bss17 Bone structure and strength QTL 17 femur morphology trait   (VT:0000559)    
Bss18 Bone structure and strength QTL 18 femur width   (VT:1000666)    
Bss19 Bone structure and strength QTL 19 femur morphology trait   (VT:0000559)    
Bss2 Bone structure and strength QTL 2 femur strength trait   (VT:0010010)    
Bss20 Bone structure and strength QTL 20 femur morphology trait   (VT:0000559)    
Bss21 Bone structure and strength QTL 21 femur morphology trait   (VT:0000559)    
Bss3 Bone structure and strength QTL 3 femur morphology trait   (VT:0000559)    
Bss4 Bone structure and strength QTL 4 femur strength trait   (VT:0010010)    
Bss5 Bone structure and strength QTL 5 femur strength trait   (VT:0010010)    
Bss6 Bone structure and strength QTL 6 lumbar vertebra strength trait   (VT:0010574)    
Bss7 Bone structure and strength QTL 7 femur strength trait   (VT:0010010)    
Bss8 Bone structure and strength QTL 8 lumbar vertebra strength trait   (VT:0010574)    
Bss9 Bone structure and strength QTL 9 femur morphology trait   (VT:0000559)    
Eau4 Experimental allergic uveoretinitis QTL 4 uvea integrity trait   (VT:0010551)    
Eau5 Experimental allergic uveoretinitis QTL 5 uvea integrity trait   (VT:0010551)    
Eau6 Experimental allergic uveoretinitis QTL 6 uvea integrity trait   (VT:0010551)    
Eau7 Experimental allergic uveoretinitis QTL 7 uvea integrity trait   (VT:0010551)    
Eau8 Experimental allergic uveoretinitis QTL 8 uvea integrity trait   (VT:0010551)    
Eau9 Experimental allergic uveoretinitis QTL 9 uvea integrity trait   (VT:0010551)    
Glom15 Glomerulus QTL 15 kidney glomerulus integrity trait   (VT:0010546)    
Glom16 Glomerulus QTL 16 kidney glomerulus integrity trait   (VT:0010546)    
Glom22 Glomerulus QTL 22 urine protein amount   (VT:0005160)    
Glom23 Glomerulus QTL 23 urine protein amount   (VT:0005160)    
Glom24 Glomerulus QTL 24 kidney glomerulus integrity trait   (VT:0010546)    
Glom25 Glomerulus QTL 25 urine protein amount   (VT:0005160)    
Glom26 Glomerulus QTL 26 urine protein amount   (VT:0005160)    
Stresp4 Stress response QTL 4 blood corticosterone amount   (VT:0005345)    
Stresp5 Stress response QTL 5 blood corticosterone amount   (VT:0005345)    

Additional Information

RGD Curation Notes
Note Type Note Reference
strain_other These have shorter survival time after controlled hemorrhage than BN/HsdMcwiCrl but longer than DA/OlaHsd. 2302114

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2014-09-25 LEW/NHsd    LEW/NHsd    Name updated 68913 APPROVED
2014-09-25 LEW/NHsd    LEW/NHsd    Name updated 68913 APPROVED