Strain Report - Rat Genome Database

Name: SD- Lepr em3
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Strain Registration

General

Strain: SD-Lepr^em3

Symbol:

SD-Lepr^em3

Strain:

SD-Lepr^em3

RGD ID:

12910519

Citation ID:

RRID:RGD_12910519

Ontology ID:

RS:0004468

Alleles:

Lepr^em3

Previously known as:

lepr^in18/in18; SD-Leprem3

Type:

mutant

Source:

East China Normal University, Shanghai, China

Origin:

This strain was produced by injecting TALEN targeting the sequence of rat Lepr into SD embryos. The resulting mutation is a 18-bp insertion.

Last Known Status:

Unknown

Position

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	5	116,294,409 - 116,477,904	RGD_MAPPER_PIPELINE	mRatBN7.2
Rnor_6.0	5	120,503,475 - 120,682,281	RGD_MAPPER_PIPELINE	Rnor6.0
Rnor_5.0	5	124,380,327 - 124,556,585	RGD_MAPPER_PIPELINE	Rnor5.0
RGSC_v3.4	5	122,320,075 - 122,503,449	RGD_MAPPER_PIPELINE	RGSC3.4

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

obesity (IMP)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

impaired glucose tolerance (IMP)

increased circulating alanine transaminase level (IMP)

increased circulating aspartate transaminase level (IMP)

increased circulating cholesterol level (IMP)

increased circulating triglyceride level (IMP)

increased fat cell size (IMP)

References

References - curated

#	Reference Title	Reference Citation
1.	Generation of obese rat model by transcription activator-like effector nucleases targeting the leptin receptor gene.	Chen Y, etal., Sci China Life Sci. 2017 Feb;60(2):152-157. doi: 10.1007/s11427-016-5049-y. Epub 2016 May 25.

Region

Additional Information

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Strain: SD-Leprem3

Mammalian Phenotype

Strain: SD-Lepr^em3