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Strain Registration

Strain: F344-Atmm1Kyo

Symbol: F344-Atmm1Kyo
Strain: F344-Atmm1
Substrain: Kyo
Full Name: Atm missense rats
RGD ID: 12879394
Citation ID: RRID:RGD_12879394
Ontology ID: RS:0004407
Alleles: Atmm1Kyo
Also Known As: NBRP No.0627; F344-Atmm1Kyo; F344-Atm^[m1Kyo]
Type: mutant
Available Source: National BioResource Project for the Rat in Japan
Origination: National BioResource Project for the Rat in Japan
Description: This strain is an Atm missense mutant (amino acid change of leucine (L) to proline (P) at position 2262 (L2262P))rat and was established by ENU mutagenesis using F344/NSlc strain.
Genetic Status: Heterozygous
Coat Color: Albino
Inbred Generations: N4 (April 2012)
Last Known Status: Live Animals; Cryopreserved Sperm (as of 2017-04-18)
Research Usage Immunology
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2853,854,010 - 53,854,010RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.0858,041,203 - 58,041,203RGD_MAPPER_PIPELINERnor6.0
Rnor_5.0856,598,503 - 56,703,115RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.4856,894,746 - 56,996,565RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Strains registered by the National Bio Resource Project for the Rat in Japan Personal Communication with NBRP
2. A rat model of ataxia-telangiectasia: evidence for a neurodegenerative phenotype. Quek H, etal., Hum Mol Genet. 2017 Jan 1;26(1):109-123. doi: 10.1093/hmg/ddw371.
3. Rats with a missense mutation in Atm display neuroinflammation and neurodegeneration subsequent to accumulation of cytosolic DNA following unrepaired DNA damage. Quek H, etal., J Leukoc Biol. 2017 Apr;101(4):927-947. doi: 10.1189/jlb.4VMA0716-316R. Epub 2016 Nov 28.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Atmm1Kyo-var1 chr8 53854010 53854010 A G point_mutation mRatBN7.2
Atmm1Kyo-var1 chr8 58041203 58041203 A G point_mutation Rnor_6.0

Additional Information