Strain Report - Rat Genome Database

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Strain: Ho:ZFDM-Leprfa

Symbol: Ho:ZFDM-Leprfa
Strain: ZFDM-Leprfa
Substrain: Ho
Full Name: Zucker Fatty Diabetes Mellitus rats
RGD ID: 12859279
Citation ID: RRID:RGD_12859279
Ontology ID: RS:0004404
Alleles: Leprfa;   Lepr
Previously known as: Hos:ZFDM-Leprfa; ZFDM rats; Ho:ZFDM-Leprfa
Type: outbred
Source: Hoshino Laboratory Animals, Inc. (Ibaraki, Japan)
Origin: In the Zucker fatty rat colony in Hoshino Laboratory Animals, Inc, they incidentally found fa/fa homozygous male rats having reproductive ability. The Selective breeding using the fa/fa male rats that exhibited relatively high blood glucose levels at 10 weeks of age, resulting in establishment of a diabetic strain. These fa/fa male rats developed diabetes as early as 10 weeks of age, reaching 100% incidence by 21 weeks of age, while none of the fa/+ male rats developed diabetes.
Last Known Status: Unknown


References - curated
# Reference Title Reference Citation
1. Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat. Gheni G, etal., J Diabetes Res. 2015;2015:261418. doi: 10.1155/2015/261418. Epub 2015 Apr 16.
2. A Novel Rat Model of Type 2 Diabetes: The Zucker Fatty Diabetes Mellitus ZFDM Rat. Yokoi N, etal., J Diabetes Res. 2013;2013:103731. doi: 10.1155/2013/103731. Epub 2013 Feb 26.


Damaging Variants
Number of Damaging Variants
ZFDM (KyushuU) 1162

Rat Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type
Leprfa-var1 chr5 116389200 116389200 A C point_mutation
Leprfa-var1 chr5 120597857 120597857 A C point_mutation

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-16 Ho:ZFDM-Leprfa  Zucker Fatty Diabetes Mellitus rats  Ho:ZDFM-Leprfa  Zucker Fatty Diabetes Mellitus rats  Symbol and/or name change 68913 APPROVED
2018-03-14 Ho:ZDFM-Leprfa  Zucker Fatty Diabetes Mellitus rats  Ho:ZDFM-Leprfa   Zucker Fatty Diabetes Mellitus rats  Symbol updated 68687 APPROVED